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'Supercooling' keeps organs fresh

Written By Unknown on Senin, 30 Juni 2014 | 21.24

29 June 2014 Last updated at 18:08 By James Gallagher Health editor, BBC News online

A new technique can preserve organs for days before transplanting them, US researchers claim.

"Supercooling" combines chilling the organ and pumping nutrients and oxygen through its blood vessels.

Tests on animals, reported in the journal Nature Medicine, showed supercooled livers remained viable for three days, compared with less than 24 hours using current technology.

If it works on human organs, it has the potential to transform organ donation.

As soon as an organ is removed from the body, the individual cells it is made from begin to die.

Cooling helps slow the process as it reduces the metabolic rate of the cells.

Meanwhile, surgeons in the UK carried out the first "warm liver" transplant in March 2013 which used an organ kept at body temperature in a machine.

The technique being reported first hooks the organ up to a machine which perfuses the organ with nutrients.

It is then cooled to minus 6C.

Supercool

In experiments on rat livers, the organs could be preserved for three days.

One of the researchers, Dr Korkut Uygun, from the Harvard Medical School, told the BBC the technique could lead to donated organs being shared around the world.

"That would lead to better donor matching, which would reduce-long term organ rejection and complications, which is one of the major issues in organ transplant," he said.

He also argued that organs which are normally rejected, as they would not survive to the transplant table, might be suitable if they were preserved by supercooling.

"That could basically eliminate waiting for a organ, but that is hugely optimistic," Dr Uygun said.

Further experiments are now needed to see if the technology can be scaled up from preserving a 10g (0.35oz) rat liver to a 1.5kg (3.3lb) human liver.

The researchers believe the technology could work on other organs as well.

Dr Rosemarie Hunziker, from the US National Institute of Biomedical Imaging and Bioengineering, said: "It is exciting to see such an achievement in small animals by recombining and optimising existing technology.

"The longer we are able to store donated organs, the better the chance the patient will find the best match possible, with both doctors and patients fully prepared for surgery.

"This is a critically important step in advancing the practice of organ storage for transplantation."


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Give NHS more cash, say coalition MPs

29 June 2014 Last updated at 18:47

The NHS needs more money to avoid a funding crisis, senior Conservative and Lib Dem MPs have warned.

Sarah Wollaston, Conservative chair of the Commons health select committee, said the NHS was facing "crunch time".

Her comments were echoed by Lib Dem former health minister Paul Burstow who warned the NHS could collapse within five years without extra money.

The Department of Health said it was confident of making £20bn in savings to reinvest in frontline care.

Mr Burstow put the level of extra funding needed for the NHS to function properly at £15bn over five years.

Ageing population
Continue reading the main story

Are we going to be able to increase funding, or will something have to give?"

End Quote Dr Sarah Wollaston Commons health select committee chairwoman

Dr Wollaston told the BBC the NHS was "coping remarkably well" but that future funding was "under immense pressure".

She said: "We have protected spending on health. It is rising in line - just above - background inflation, but inflation in the health sector is much higher because we have got an ageing population.

"So many more people are living with several long-term conditions and of course we have got amazing advances in technology and we need to be able to fund all those things."

Dr Wollaston said the service was not "doomed to failure" but added: "We know that over the next few years, we are going to run into a real crunch time with funding and what's necessary now is for NHS England to set out very clearly what can be achieved within various funding limits.

"In other words - are we going to be able to increase funding, or will something have to give?"

She added: "Personally, I'd like to see services continue to improve, so I think in order to achieve that we are going to need an increase in funding."

Dr Wollaston said it would be "key" to "get the best value out of the resources we have" over the coming years.

'Rising demand'

Stephen Dorrell, also a Conservative and her predecessor as chair of the health select committee, said he would be ashamed if the government failed to increase NHS funding when the economy was growing.

"I am in favour of the government not denying what 5,000 years of history tells us is true, which is that every time a society gets richer it spends a rising share of its income on looking after the sick and the vulnerable," he told The Observer.

A Department of Health spokeswoman said: "We've taken tough decisions to protect the NHS budget, which is allowing us to strengthen family doctoring, reform out of hospital care, and improve GP access for 7.5 million people across the country.

"The NHS is also on track to make £20bn [in] savings this parliament to reinvest into frontline care and we are confident that it will continue to make the savings necessary to meet rising demand."

The MPs' comments on funding came as the health secretary spoke of plans to publicly name GPs with a poor record in spotting signs of cancer.

Jeremy Hunt said he wanted to expose doctors whose failure to spot cancer may delay patients receiving potentially life-saving scans.

Doctors found to be missing too many cases of cancer or with patients who are forced to make repeated visits before being referred for tests would be marked with a red flag. Those found with quick referral times for patients would be given a green rating.

The Royal College of GPs said it would be a "crude" system and one that could lead to GPs sending people to specialists indiscriminately. It warned this could result in flooding hospitals with healthy people.


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Older sperm donors 'just as good'

30 June 2014 Last updated at 01:57 By James Gallagher Health editor, BBC News online

Women should not worry about using sperm from older donors as the success rate is the same as using a younger man's sperm, researchers say.

The average age of donors has risen in the UK since the right to anonymity was removed in 2005.

Doctors said there was concern about the impact on the odds of a pregnancy.

Experts said only older men with the best sperm could donate, so men as a whole should not see the results as an excuse to delay fatherhood.

A presentation at the European Society of Human Reproduction and Embryology annual conference showed the average age of donors was 26 before the law change and 34 afterwards.

"It is a huge difference," said Dr Meenakshi Choudhary from the Newcastle Fertility Centre.

"It may concern women, who are already older, who know their chances are lower, that if they go for an older sperm then their chance of a live birth will be further reduced and compromised."

She analysed data from 39,282 cycles of IVF between 1991 and 2012, concluding that older men had the same success rates as younger men.

Dr Meenakshi Choudhary told the BBC: "It doesn't matter up to the age of 45 years, there was no decline observed in this study.

"Sperm donors are a select group of the population, they are healthy fertile donors who go through a stringent recruitment criteria.

"Based on this we can say that age does not matter as long as the sperm quality is good."

'Men not invincible'

Dr Allan Pacey, a lecturer in sperm at the University of Sheffield, said men should not be tempted by complacency.

He told the BBC: "I think there is a perception out there that men are invincible from reproductive ageing - we just need to look at Charlie Chaplin who was 73 when he had his eleventh child.

"We know that as men go above the age of 40 and go into their fifties, their chances of getting a woman pregnant does reduce as a consequence of age.

"I don't think you can take this data and apply it uncritically to the general population, the advice would still be you should be trying to have a child before the age of 40 or 45."


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UK facing 'major' sperm shortage

Written By Unknown on Minggu, 29 Juni 2014 | 21.24

28 June 2014 Last updated at 00:07 By James Gallagher Health editor, BBC News online

The UK is facing a major sperm shortage that may be tempting fertility clinics to accept poorer quality sperm, the British Fertility Society (BFS) warns.

Some clinics rely on imported sperm to keep up with demand.

However, the BFS chairman, Dr Allan Pacey, said he was "worried" that some clinics may be setting a lower bar to "get donors through the door".

He said women may be subjected to more invasive and expensive techniques if poor-quality sperm were used.

There are thought to have been fewer sperm donors after the right to anonymity was removed in 2005.

The demand for donors has been falling as advances in fertility treatment let more men father their own children.

However, a shortage of donors has still emerged.

Figures from the fertility regulator, the Human Fertilisation and Embryology Authority (HFEA), show nearly one in four donated sperm samples is from abroad.

The figure was one in 10 in 2005.

Sperm banks in Denmark and the US are the major suppliers.

Dr Pacey warned this was limiting patient choice and increasing waiting times, which led to potential risky practices, including DIY insemination with a friend's sperm or seeking treatment in a country with less fertility regulation.

He told the BBC: "We do still have a major sperm shortage in the UK.

"The worry is clinics might decide to change the quality of sperm they are willing to accept in order to get donors through the door and I think that's a very dangerous road to go down."

He said one possible example was sperm being accepted that would be suitable only for injecting into an egg - intra-cytoplasmic sperm injection - rather than for artificial insemination.

"That is putting the woman through more procedures, in terms of eggs being collected, than would be done if sperm of higher quality was collected and she could be treated with a simple insemination.

"My worry is clinics may be tempted to bend the rules, I have no evidence that they are, but I think when we have a national sperm shortage they're the kind of things we need to be looking for and warding against."

'Fully inform patients'

Professor Yakoub Khalaf, of the assisted conception unit at Guy's Hospital in London, commented: "We are now more reliant on external sperm banks than ever before.

"I don't think it is an issue as such, but what I have observed is that when people get sperm from abroad they can be given an option of 'suitable for insemination', or 'suitable for IVF or ICSI' [sperm injected to the egg].

"But how can donor sperm be less than adequate for all treatments?"

He said that based on his experience of the quality of imported sperm "the same could be happening here".

A HFEA spokesperson said: "We expect our clinics to use only donor sperm of a quality that will ensure the best outcome for the patient, and under our code of practice clinics are required to fully inform patients of the different treatment options available to them."


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Leukaemia clue in breast cancer

27 June 2014 Last updated at 00:42

Leukaemia research may lead to new drugs for difficult-to-treat breast cancers, say scientists.

These types of tumours cannot be treated with the targeted drugs which have hugely improved survival.

A team in Glasgow says a faulty piece of DNA which causes leukaemia also has a role in some tumours and could help in research for new drugs.

Meanwhile, other researchers say they have taken tentative steps towards a blood test for breast cancer.

Oestrogen or progesterone positive breast cancers can be treated with hormone therapies such as Tamoxifen.

Another drug, Herceptin, works only on those tumours which are HER2-positive.

But around one in five breast cancers is "triple negative" meaning chemotherapy, radiotherapy or surgery are the only options.

Leukaemia

A team at the University of Glasgow investigated the role of the RUNX1 gene, which is one of the most commonly altered genes in leukaemia.

However, they have now shown it is also active in the most deadly of triple negative breast cancers.

Tests on 483 triple negative breast cancers showed patients testing positive for RUNX1 were four times more likely to die as a result of the cancer than those without it.

The results were published in the journal PLoS One.

One of the researchers, Dr Karen Blyth, said: "This opens up the exciting possibility of using it [RUNX1] as a new target for treatments."

She told the BBC: "First we need to prove this gene is causative to the cancer, if it is then what would happen if we did inhibit it?

"There's a couple of drugs in development in the US to target this gene from a leukaemia point of view, if they work we can test it in breast cancer cells."

However, the gene has a complex role. Normally it is vital for cell survival and plays a critical role in producing blood. However, depending on circumstances, it can either encourage or suppress tumours.

It means any use of a drug to target the gene might cause side-effects.

Dr Kat Arney, the science communications manager at Cancer Research UK, said: "There's still so much we need to understand about triple negative breast cancers, as they can be harder to treat in some people.

"Almost two out of three women with breast cancer now survive their disease beyond 20 years.

"But more must be done and we urgently need more studies like these, particularly in lesser-understood forms of the disease, to build on the progress we've already made and save more lives."

Blood test

In a separate development, scientists at University College London think they have taken the first steps towards a blood test for breast cancer.

They found changes in the DNA of immune cells in the blood of women who were at high risk of breast cancer as they had inherited the BRCA1 risk gene.

Prof Martin Widschwendter, from UCL said: "Surprisingly, we found the same signature in large cohorts of women without the BRCA1 mutation and it was able to predict breast cancer risk several years before diagnosis."

They think it could become the basis of a blood test.

Dr Matthew Lam, senior research officer at Breakthrough Breast Cancer, said: "These results are definitely promising and we're excited to learn how further research could build on these findings."


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GPs who miss cancer could be named

29 June 2014 Last updated at 14:24
GP and patient

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The BMA's Dr Chaand Nagpaul says naming and shaming is not the answer

GPs with a poor record in spotting signs of cancer could be publicly named under new government plans.

Health Secretary Jeremy Hunt wants to expose doctors whose failure to spot cancer may delay sending patients for potentially life-saving scans.

Labour called the idea "desperate" and accused Mr Hunt of attacking doctors.

The Royal College of GPs said it would be a "crude" system and one that could lead to GPs sending people to specialists indiscriminately.

It warned this could result in flooding hospitals with healthy people.

The move is part of the health secretary's plans to make the NHS more transparent.

Ranking GP surgeries on how quickly they spot cases of cancer and refer patients for treatment is among proposals being considered.

The information could eventually be published on the NHS website.

This follows a survey for the NHS last year, which suggested that more than a quarter of people eventually diagnosed with cancer had seen their GP at least three times before being sent to a specialist.

Continue reading the main story

If you simply name and shame GPs, the tendency would be for us to refer everyone"

End Quote Chaand Nagpaul BMA

"We need to do much better," the health secretary told the Mail on Sunday.

"Cancer diagnosis levels around the country vary significantly and we must do much more to improve both the level of diagnosis and to bring those GP practices with poor referral rates up to the standards of the best."

Doctors found to be missing too many cases of cancer or with patients who are forced to make repeated visits before being referred for tests would be marked with a red flag.

A patient's story

Susan has a sister with terminal cancer.

She told the BBC: "My sister was first told she had a prolapsed womb, then piles.

"By the time she was seen by an oncologist, eight months had elapsed.

"She has terminal squamous cell anal cancer - completely curable if caught early enough.

"She is 62, and now has a few months to live.

"One of the classic mistakes the GP made was to diagnose anal bleeding as piles. It wasn't - it was the tumour.

"This doctor has condemned my sister to a year, so far, of terrible suffering and a death which is too dreadful to contemplate, when she could have been completely cured.

"Prognosis is something like 96% complete cure if treated early."

Susan believes her sister's GP should be "named and shamed" but thinks each case should be considered on an individual basis.

"As a retired teacher, I know what being continually maligned, judged, overlooked and overloaded can do to morale and performance," she added.

Those found with quick referral times for patients would be given a green rating.

Shadow health minister Jamie Reed said the government would not take responsibility for problems it had created in the NHS.

"David Cameron wasted billions on a re-organisation nobody wanted and left cancer patients waiting longer for tests and treatment. He should be ashamed of his own record - not attacking doctors," he said.

"This government has thrown away progress made on cancer care. It is proof of why the Tories can't be trusted with the NHS."

'Clog up clinics'

Dr Chaand Nagpaul, chair of the British Medical Association general practitioners committee, said to name and shame doctors would not help patients.

He said it was important to understand why there were delays in making referrals and to raise public awareness about the signs and symptoms of cancer.

"We need to look at the whole system and if you simply name and shame GPs, the tendency would be for us to refer everyone," he told the BBC.

"And that can be a disadvantage because if we clog up hospital outpatient clinics, we'll get patients who need to see their specialist actually having to wait longer."

Conservative MP Sarah Wollaston, a former GP who chairs the Commons health select committee, said the government needed to be careful not to wrongly label people as "poor doctors".

She too warned there was a danger of automatically referring everyone to a specialist and creating "impossibly long waiting lists", which could harm those needing to be seen urgently.

Rising demand

Dr Wollaston added that she could not see how GPs could maintain current levels of service amid rising demand without a funding injection.

"The NHS budget has been protected in line with background inflation but that does not keep pace with inflation in health costs from rising demand and demographic changes," she said.

"I don't want to see any reduction in services. I would like to see further improvements and that will require an increase in funding."

Dr Wollaston joined Conservative former health secretary Stephen Dorrell and Lib Dem former health minister Paul Burstow in calling for increased funding for the NHS.

Mr Burstow warned that the NHS was in danger of collapse within five years without extra spending. He said the health service needed an extra £15bn over that period in order to function properly.

Mr Dorrell said he would be ashamed if the government failed to increase NHS funding at a time when the economy was growing.

"I am in favour of the government not denying what 5,000 years of history tells us is true, which is that every time a society gets richer it spends a rising share of its income on looking after the sick and the vulnerable," he told The Observer.


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UK facing 'major' sperm shortage

Written By Unknown on Sabtu, 28 Juni 2014 | 21.24

28 June 2014 Last updated at 00:07 By James Gallagher Health editor, BBC News online

The UK is facing a major sperm shortage that may be tempting fertility clinics to accept poorer quality sperm, the British Fertility Society (BFS) warns.

Some clinics rely on imported sperm to keep up with demand.

However, the BFS chairman, Dr Allan Pacey, said he was "worried" that some clinics may be setting a lower bar to "get donors through the door".

He said woman may be subjected to more invasive and expensive techniques if poor-quality sperm were used.

There are thought to have been fewer sperm donors after the right to anonymity was removed in 2005.

The demand for donors has been falling as advances in fertility treatment let more men father their own children.

However, a shortage of donors has still emerged.

Figures from the fertility regulator, the Human Fertilisation and Embryology Authority (HFEA), show nearly one in four donated sperm samples are from abroad.

The figure was one in 10 in 2005.

Sperm banks in Denmark and the US are the major suppliers.

Dr Pacey warned this was limiting patient choice and increasing waiting times, which led to potential risky practices, including DIY insemination with a friend's sperm or seeking treatment in a country with less fertility regulation.

He told the BBC: "We do still have a major sperm shortage in the UK.

"The worry is clinics might decide to change the quality of sperm they are willing to accept in order to get donors through the door and I think that's a very dangerous road to go down."

He said one possible example was sperm being accepted that would be suitable only for injecting into an egg - intra-cytoplasmic sperm injection - rather than for artificial insemination.

"That is putting the woman through more procedures, in terms of eggs being collected, than would be done if sperm of higher quality was collected and she could be treated with a simple insemination.

"My worry is clinics may be tempted to bend the rules, I have no evidence that they are, but I think when we have a national sperm shortage they're the kind of things we need to be looking for and warding against."

'Fully inform patients'

Professor Yakoub Khalaf, of the assisted conception unit at Guy's Hospital in London, commented: "We are now more reliant on external sperm banks than ever before.

"I don't think it is an issue as such, but what I have observed is that when people get sperm from abroad they can be given an option of 'suitable for insemination', or 'suitable for IVF or ICSI' [sperm injected to the egg].

"But how can donor sperm be less than adequate for all treatments?"

He said that based on his experience of the quality of imported sperm "the same could be happening here".

A HFEA spokesperson said: "We expect our clinics to use only donor sperm of a quality that will ensure the best outcome for the patient, and under our code of practice clinics are required to fully inform patients of the different treatment options available to them."

Have you donated to a fertility clinic in the past? Would you consider doing so in the future? If you are happy to speak to a BBC journalist, please email haveyoursay@bbc.co.uk with the word "fertility" in the subject heading.


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Savile NHS victims aged five to 75

26 June 2014 Last updated at 18:40
"Jane"

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"Jane" was abused by Savile when she was staying in hospital aged 16

Ex-BBC DJ Jimmy Savile sexually assaulted victims aged five to 75 in NHS hospitals over decades of unrestricted access, investigators say.

He assaulted patients in bed, and claimed to have abused corpses, reviews into his conduct on NHS premises found.

The reports cover 28 hospitals including Leeds General Infirmary and Broadmoor psychiatric hospital.

Health Secretary Jeremy Hunt apologised to victims, saying Savile's actions "will shake our country to the core".

'Manipulative'

Savile, a Radio 1 DJ who also presented the BBC's Top Of The Pops and Jim'll Fix It, died aged 84 in October 2011 - a year before allegations that he had sexually abused children were broadcast in an ITV documentary.

The reports on Leeds General Infirmary and Broadmoor are detailed and, at times, graphic.

They explain how Savile was allowed unsupervised access to vulnerable patients, with a failure to question the risks of his unconventional and promiscuous lifestyle.

The Leeds investigation found:

  • Sixty people came forward to say they had been abused between the ages of five and 75, including staff
  • The offences ranged from lewd remarks to sexual assault and three cases of rape and took place between 1962 and 2009
  • Only nine victims told members of staff. There were a further eight female victims who met Savile at the hospital, but were not patients
  • Savile had a well-known fixation with the dead and the report contains allegations he posed for photographs and performed sex acts on corpses in the hospital mortuary
  • While there is no way to verify the claim, Dr Sue Proctor - who led the Leeds inquiry - said there is no doubt controls on access to the mortuary were "lax"
  • Patients, including teenagers recovering from surgery, were abused in their beds
  • A 10-year-old boy was sexually assaulted while he waited on a trolley for an x-ray on his broken arm
  • A number of organisational failures over the years enabled Savile to continue unchallenged
  • The situation allowed someone "as manipulative as Savile to thrive and continue his abusive behaviour unchecked for years"

Mr Hunt told the Commons one victim being treated at Leeds General Infirmary feared she was pregnant after being abused.

There were also reports that Savile made jewellery out of glass eyes taken from dead bodies from the hospital mortuary, he told MPs.

A victim's story

Sixty people have recounted how they were abused by Savile at Leeds General Infirmary, many were young people and teenagers.

One victim "Jane" - who was 16 when she was assaulted - told the BBC Savile took her to a local shop to buy sweets and magazine, but soon afterwards sexually assaulted her in a hospital basement.

"He pulled me in immediately and started to kiss me with his tongue", she said.

"At the same time his left hand went on to my right thigh under my dress."

"There was no conversation up until that point. I couldn't have said anything even if I'd wanted to, because he had his tongue in my mouth, which wasn't pleasant".

After the assault she said she felt "dirty and ridiculously stupid". She said she began to tell nurses about the incident but when they laughed felt she couldn't finish.

"All the staff accepted it, patients accepted it, clearly the porters accepted it as well."

Mr Hunt apologised on behalf of the government and the NHS, saying of the victims: "We let them down badly."

The health secretary said there was a "deep sense of revulsion" over the findings.

Continue reading the main story

"Start Quote

When complaints were made about Savile, victims were either told that they simply would not be believed or they received responses like 'oh, that's just Jimmy'"

End Quote

He added: "As a nation, at that time we held Savile in our affection as a somewhat eccentric national treasure with a strong commitment to charitable causes.

"Today's report shows that in reality he was a sickening and prolific sexual abuser who repeatedly exploited the trust of a nation for his own vile purposes."

Mr Hunt is writing to all NHS trusts asking them to ensure they are confident about patient safety.

A spokesman for Prime Minister David Cameron said he was "deeply shocked", adding it was "important lessons are learned".

'Worst nightmare'

The Leeds report was clear that no one person is to blame for what happened at the hospital other than Savile. But it did describe a lack of curiosity about his activities.

Lesley McLean, Victim Support manager for West Yorkshire, said: "The parents of the children [Savile] abused in Leeds hospitals were already anxious about their child's health.

"What they thought was a treat for their loved one was actually their worst nightmare."

Leeds Teaching Hospitals Trust issued a statement apologising to "each and every one of Savile's victims".

"There should have been far more scrutiny of him and what he was doing at our hospitals over the years, and more robust safeguards and internal controls in place to protect our staff and patients in our care," chief executive Julian Hartley said.

In 1988, Savile was appointed by the Department of Health as the head of a taskforce overseeing Broadmoor.

The report describes an inappropriate culture at Broadmoor that allowed sexual liaisons between staff and patients and discouraged reporting of concerns.

The Broadmoor report found:

  • Savile watched and made inappropriate comments when female patients stripped and showered naked in front of staff, a practice which was common in the late 1980s
  • The late DJ was "narcissistic, arrogant and lacking in any empathy"
  • He was also very manipulative and staff were convinced he had close connections in high places
  • There was "no evidence that those responsible knew anything of the very much darker side" to Savile that was later revealed
  • Eleven allegations of sexual abuse were reported to the review. Six of them involved patients, two staff and three children

The report said the numbers were very likely to be an underestimate of the true picture because so many former patients simply wished to forget their time at Broadmoor.

'Feared sacking'

Noami Stanley, a psychiatric nurse who treated patients who told her they had been abused by Savile at Broadmoor, said police and senior medical staff dismissed her concerns as an "irritation".

She told BBC Radio 4's World at One: "I explained what I heard and what I believed was going on in Broadmoor.

Jimmy Savile in 1965

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"There was a pair of police officers who appeared surprised and looked immediately to my superiors as if to say 'do something about this woman, she's nuts'."

She said of the senior nursing officer present: "He gave me quite a severe ticking office and said if I ever ever spoke out of turn like that again I would receive a disciplinary and might get sacked."

Marjorie Wallace - now chief executive of the charity Sane - also visited the hospital regularly in the 1980s when she was researching a book.

She said there was "obviously something sinister" about the DJ and attempted to raise the alarm after witnessing his treatment of two female patients: "I went to the Department of Health and said 'What is Jimmy Savile doing here?"

But she says she was told Savile was bringing Broadmoor out of the "dark ages" and that he was a "good person, liberating this closed institution".

Labour's Andy Burnham said giving Savile "gold-plated keys" to the hospital was "one of the greatest failures in public protection and patient safety we've ever seen".

The shadow health secretary called for an over-arching, independent inquiry into the scandal.

"It would appear Savile was appointed to this role without any background checks at all," he told the BBC. "There needs to be more independent scrutiny of how the government of the day handled this."

Dr Sue Proctor

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Dr Sue Proctor on mortuary allegations - This clip contains some disturbing content

Reports have been issued on: St Catherine's Hospital (Birkenhead); Saxondale Mental Health Hospital; Portsmouth Royal Hospital; Dewsbury and District Hospital (including Pinderfields Hospital); High Royds Psychiatric Hospital; Cardiff Royal Infirmary; Great Ormond Street Hospital; Exeter Hospital; Ashworth Hospital; Barnet General Hospital; Booth Hall; De La Pole Hospital; Dryburn Hospital; Hammersmith Hospital; Leavesden Secure Mental Health Hospital; Marsden Hospital; Maudsley Hospital; Odstock Hospital; Prestwich Psychiatric Hospital; Queen Victoria Hospital, East Grinstead; Royal Victoria Infirmary; Queen Mary's Hospital, Carshalton; Whitby Memorial Hospital; Wythenshawe Hospital, and Woodhouse Eaves Children's Convalescent Homes in Leicester.

A report about Wheatfield's Hospice, which is run by the Sue Ryder charity, has also been released.

Leicestershire Police has launched an investigation after one victim of Savile, who was abused as a young boy at a children's convalescent home in Woodhouse Eaves, told an enquiry team the entertainer was involved in the death of another child.

However, no reference to a child's death could be found in the records of the home, Roecliffe Manor, which closed in 1969.

Analysis by Nick Triggle, health correspondent, BBC News

Since the allegations about Jimmy Savile came to light, the police have looked into how many victims there may have been. A review of why he was never prosecuted has also been carried out.

But this is the most comprehensive account of how he was able to offend and get away with it for so long.

Reviews into his behaviour at the BBC and care homes are expected later this year - and will no doubt shed even more light on the scandal.

But for now the failings of the NHS - an institution that is there to care for the vulnerable - are in the spotlight.

He enjoyed unsupervised access, particularly at two sites, Leeds General Infirmary and Broadmoor psychiatric hospital, and was able to use his fame to intimidate junior staff.

What is more, senior management were too unquestioning.

The reports are loathe to blame individuals.

But with cases of abuse and improper conduct being reported up until 2009 - albeit much less frequently than in the 1960s and 1970s - the NHS has a lot of soul-searching to do.

Hospital bedroom

A key report into Savile's activities at Stoke Mandeville Hospital has been delayed after new information recently came to light.

Savile had a bedroom at Stoke Mandeville, where his now-defunct charitable trust was based, as well as an office and living quarters at Broadmoor.

Reports concerning two other hospitals - Rampton and Barnet, Enfield and Haringey Mental Health Trust - have also been delayed.

There are also new investigations at Springfield Hospital and Crawley Hospital.

It is understood investigations at two hospitals - the Royal Free Hospital in London and Pennine Acute NHS hospitals Trust - found nothing to report.

The revelations made in a 2012 ITV documentary about Savile prompted more than 100 people to come forward, giving accounts of how they were sexually assaulted by Savile on NHS premises and in other places.

A report by the NSPCC said Savile abused at least 500 victims, including some as young as two.

BBC health reporter Pippa Stephens said there have been many significant changes in the law since the time Savile committed abuse.

Hospitals' Savile reports

Hospital Number of allegations Details

Leeds General Infirmary(inc St James and Seacroft Hospital)

60

33 of the 60 alleged victims were patients of whom 19 were children. A further 19 were staff. Encounters ranged from lewd remarks and inappropriate touching to sexual assault and rape.

Broadmoor Hospital

11

10 victims of assault, two were repeatedly abused. Six patients, two children and two staff. One indecent exposure to child. Report found "clear, repeated failure of safeguarding standards" at Broadmoor at the time.

St Catherine's Hospital, Birkenhead

1

Savile allegedly groped a 14-year-old female patient. Report found the victim credible and convincing. Metropolitan police have recorded it as a crime of sexual touching.

Saxondale Mental Health Hospital

1

Woman who was then 14 alleges that Savile lifted her skirt when she was at a disco at the hospital. She was a local resident rather than a patient. Savile had a fundraising association with Saxondale Hospital from 1972 to the early 1980s.

Portsmouth Royal Hospital

1

A man alleges being told by a cleaner that he was assaulted by Savile while unconscious. The report concludes that it is "highly unlikely" the incident took place.

Dewsbury and District Hospital (inc Pinderfields Hospital)

2

Woman says that when she was a 15-year-old inpatient in 1969 Savile French kissed her without permission. A second allegation relates to lewd comments overheard by a nurse.

High Royds Psychiatric Hospital

2

Patient and member of staff say they were groped by Savile at a hospital fun day. Victim accounts described as "very compelling and certainly plausible".

Wheatfield's Hospice, (non-NHS – Sue Ryder)

1

At an opening ceremony before patients were admitted, a woman who was then 16 alleges that Savile touched her leg and made lewd comments. The report found her account credible but there was no evidence to substantiate it.

Cardiff Royal Infirmary

1

Patient alleged that Savile forcefully kissed her while she was lying in bed. The investigators were "unable to reach a conclusion about whether the incident took place".

Great Ormond Street

1

One allegation of sexual abuse of a patient in 1971. Report found no evidence that Savile was at the hospital at the time.

Digby Hospital, Exeter

1

Former patient alleges that she was raped by Savile in a caravan in the hospital grounds. The report "no reason to doubt the veracity" of her account.

Ashworth / Moss Side Hospital

4

Two female ex-patients said Savile abused them. One male ex-patient said he witnessed groping. One ex-staff member speculated about abuse which may have happened. Information was found to be credible.

Barnet General Hospital

1

Patient had conversation with nurses who said they had seen Savile having sex with dead body at a different hospital. Investigators concluded incident did not happen at Barnet although conversation did take place.

Booth Hall Children's Hospital

2

Woman who was 7 or 8 at time says she was abused by her father and Savile. Man says Savile touched him when he was 10. Investigators cannot say conclusively whether the incidents took place.

De La Pole Hospital

1

Nurse alleged Savile groped a 14-16-year-old female patient but she denies the incident. Investigators found no evidence of the alleged assault but did find Savile had visited the hospital.

Dryburn Hospital

1

Allegations of potential procuring of children for Savile. No evidence was found to support this.

Hammersmith Hospital

2

One allegation related to a friend of Savile rather than Savile himself. A second allegation was of an inappropriate comment to a 13-year-old girl. No evidence of an association between the hospital and Savile.

Leavesden Secure Mental Health Hospital

0

Person thought Savile may have visited the hospital in the 1970s but report finds this unlikely.

Royal Marsden Hospital

1

Person said colleague had alleged Savile had made sexual advances to her at either the Royal Marsden or Stoke Mandeville hospitals. No evidence was found of Savile's association with Royal Marsden.

Maudsley Hospital

0

Person thought Savile may have visited in 1964/5. Report found no evidence of wrongdoing.

Odstock Hospital, Salisbury

0

Person said Savile used to visit the hospital in the 1980s. Report found no allegation of wrongdoing by Savile.

Prestwich Psychiatric Hospital

1

Woman alleges that when she was a young girl she was taken onto the hospital site by Savile and another man and abused. Report found that the alleged incident had probably occurred despite not being possible to verify her account.

Queen Victoria Hospital, East Grinstead

1

Female patient alleged she was groped as she recovered from an operation. Investigators did not doubt that the attack happened but thought Savile was not involved.

Royal Victoria Infirmary

0

People flagged up that Savile had visited the hospital in 1987 and 1991. No allegation of wrongdoing made.

Queen Mary's Hospital

1

Anonymous allegation that a junior nurse denied Savile access to a ward and was threatened that a BBC outside broadcast would be cancelled as a result. Investigators found it was not possible to conclude whether the incident occurred.

Whitby Memorial Hospital

1

Staff member said Savile had touched her inappropriately. Investigators found that the incident did take place.

Wythenshawe Hospital

1

Patient said that a fellow patient alleged that Savile was a "dirty old man" who had parties in his home with young girls. No evidence that Savile was present on the hospital site.

Woodhouse Eaves / Roecliffe Manor

1

Allegation of abuse against a boy aged 5-7. Investigators found that it was likely that abuse had happened at the location but it was not possible to conclude it was carried out by Savile.


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Leukaemia clue in breast cancer

27 June 2014 Last updated at 00:42

Leukaemia research may lead to new drugs for difficult-to-treat breast cancers, say scientists.

These types of tumours cannot be treated with the targeted drugs which have hugely improved survival.

A team in Glasgow says a faulty piece of DNA which causes leukaemia also has a role in some tumours and could help in research for new drugs.

Meanwhile, other researchers say they have taken tentative steps towards a blood test for breast cancer.

Oestrogen or progesterone positive breast cancers can be treated with hormone therapies such as Tamoxifen.

Another drug, Herceptin, works only on those tumours which are HER2-positive.

But around one in five breast cancers is "triple negative" meaning chemotherapy, radiotherapy or surgery are the only options.

Leukaemia

A team at the University of Glasgow investigated the role of the RUNX1 gene, which is one of the most commonly altered genes in leukaemia.

However, they have now shown it is also active in the most deadly of triple negative breast cancers.

Tests on 483 triple negative breast cancers showed patients testing positive for RUNX1 were four times more likely to die as a result of the cancer than those without it.

The results were published in the journal PLoS One.

One of the researchers, Dr Karen Blyth, said: "This opens up the exciting possibility of using it [RUNX1] as a new target for treatments."

She told the BBC: "First we need to prove this gene is causative to the cancer, if it is then what would happen if we did inhibit it?

"There's a couple of drugs in development in the US to target this gene from a leukaemia point of view, if they work we can test it in breast cancer cells."

However, the gene has a complex role. Normally it is vital for cell survival and plays a critical role in producing blood. However, depending on circumstances, it can either encourage or suppress tumours.

It means any use of a drug to target the gene might cause side-effects.

Dr Kat Arney, the science communications manager at Cancer Research UK, said: "There's still so much we need to understand about triple negative breast cancers, as they can be harder to treat in some people.

"Almost two out of three women with breast cancer now survive their disease beyond 20 years.

"But more must be done and we urgently need more studies like these, particularly in lesser-understood forms of the disease, to build on the progress we've already made and save more lives."

Blood test

In a separate development, scientists at University College London think they have taken the first steps towards a blood test for breast cancer.

They found changes in the DNA of immune cells in the blood of women who were at high risk of breast cancer as they had inherited the BRCA1 risk gene.

Prof Martin Widschwendter, from UCL said: "Surprisingly, we found the same signature in large cohorts of women without the BRCA1 mutation and it was able to predict breast cancer risk several years before diagnosis."

They think it could become the basis of a blood test.

Dr Matthew Lam, senior research officer at Breakthrough Breast Cancer, said: "These results are definitely promising and we're excited to learn how further research could build on these findings."


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Savile NHS victims aged five to 75

Written By Unknown on Jumat, 27 Juni 2014 | 21.24

26 June 2014 Last updated at 18:40
"Jane"

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"Jane" was abused by Savile when she was staying in hospital aged 16

Ex-BBC DJ Jimmy Savile sexually assaulted victims aged five to 75 in NHS hospitals over decades of unrestricted access, investigators say.

He assaulted patients in bed, and claimed to have abused corpses, reviews into his conduct on NHS premises found.

The reports cover 28 hospitals including Leeds General Infirmary and Broadmoor psychiatric hospital.

Health Secretary Jeremy Hunt apologised to victims, saying Savile's actions "will shake our country to the core".

'Manipulative'

Savile, a Radio 1 DJ who also presented the BBC's Top Of The Pops and Jim'll Fix It, died aged 84 in October 2011 - a year before allegations that he had sexually abused children were broadcast in an ITV documentary.

The reports on Leeds General Infirmary and Broadmoor are detailed and, at times, graphic.

They explain how Savile was allowed unsupervised access to vulnerable patients, with a failure to question the risks of his unconventional and promiscuous lifestyle.

The Leeds investigation found:

  • Sixty people came forward to say they had been abused between the ages of five and 75, including staff
  • The offences ranged from lewd remarks to sexual assault and three cases of rape and took place between 1962 and 2009
  • Only nine victims told members of staff. There were a further eight female victims who met Savile at the hospital, but were not patients
  • Savile had a well-known fixation with the dead and the report contains allegations he posed for photographs and performed sex acts on corpses in the hospital mortuary
  • While there is no way to verify the claim, Dr Sue Proctor - who led the Leeds inquiry - said there is no doubt controls on access to the mortuary were "lax"
  • Patients, including teenagers recovering from surgery, were abused in their beds
  • A 10-year-old boy was sexually assaulted while he waited on a trolley for an x-ray on his broken arm
  • A number of organisational failures over the years enabled Savile to continue unchallenged
  • The situation allowed someone "as manipulative as Savile to thrive and continue his abusive behaviour unchecked for years"

Mr Hunt told the Commons one victim being treated at Leeds General Infirmary feared she was pregnant after being abused.

There were also reports that Savile made jewellery out of glass eyes taken from dead bodies from the hospital mortuary, he told MPs.

A victim's story

Sixty people have recounted how they were abused by Savile at Leeds General Infirmary, many were young people and teenagers.

One victim "Jane" - who was 16 when she was assaulted - told the BBC Savile took her to a local shop to buy sweets and magazine, but soon afterwards sexually assaulted her in a hospital basement.

"He pulled me in immediately and started to kiss me with his tongue", she said.

"At the same time his left hand went on to my right thigh under my dress."

"There was no conversation up until that point. I couldn't have said anything even if I'd wanted to, because he had his tongue in my mouth, which wasn't pleasant".

After the assault she said she felt "dirty and ridiculously stupid". She said she began to tell nurses about the incident but when they laughed felt she couldn't finish.

"All the staff accepted it, patients accepted it, clearly the porters accepted it as well."

Mr Hunt apologised on behalf of the government and the NHS, saying of the victims: "We let them down badly."

The health secretary said there was a "deep sense of revulsion" over the findings.

Continue reading the main story

"Start Quote

When complaints were made about Savile, victims were either told that they simply would not be believed or they received responses like 'oh, that's just Jimmy'"

End Quote

He added: "As a nation, at that time we held Savile in our affection as a somewhat eccentric national treasure with a strong commitment to charitable causes.

"Today's report shows that in reality he was a sickening and prolific sexual abuser who repeatedly exploited the trust of a nation for his own vile purposes."

Mr Hunt is writing to all NHS trusts asking them to ensure they are confident about patient safety.

A spokesman for Prime Minister David Cameron said he was "deeply shocked", adding it was "important lessons are learned".

'Worst nightmare'

The Leeds report was clear that no one person is to blame for what happened at the hospital other than Savile. But it did describe a lack of curiosity about his activities.

Lesley McLean, Victim Support manager for West Yorkshire, said: "The parents of the children [Savile] abused in Leeds hospitals were already anxious about their child's health.

"What they thought was a treat for their loved one was actually their worst nightmare."

Leeds Teaching Hospitals Trust issued a statement apologising to "each and every one of Savile's victims".

"There should have been far more scrutiny of him and what he was doing at our hospitals over the years, and more robust safeguards and internal controls in place to protect our staff and patients in our care," chief executive Julian Hartley said.

In 1988, Savile was appointed by the Department of Health as the head of a taskforce overseeing Broadmoor.

The report describes an inappropriate culture at Broadmoor that allowed sexual liaisons between staff and patients and discouraged reporting of concerns.

The Broadmoor report found:

  • Savile watched and made inappropriate comments when female patients stripped and showered naked in front of staff, a practice which was common in the late 1980s
  • The late DJ was "narcissistic, arrogant and lacking in any empathy"
  • He was also very manipulative and staff were convinced he had close connections in high places
  • There was "no evidence that those responsible knew anything of the very much darker side" to Savile that was later revealed
  • Eleven allegations of sexual abuse were reported to the review. Six of them involved patients, two staff and three children

The report said the numbers were very likely to be an underestimate of the true picture because so many former patients simply wished to forget their time at Broadmoor.

'Feared sacking'

Noami Stanley, a psychiatric nurse who treated patients who told her they had been abused by Savile at Broadmoor, said police and senior medical staff dismissed her concerns as an "irritation".

She told BBC Radio 4's World at One: "I explained what I heard and what I believed was going on in Broadmoor.

Jimmy Savile in 1965

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"There was a pair of police officers who appeared surprised and looked immediately to my superiors as if to say 'do something about this woman, she's nuts'."

She said of the senior nursing officer present: "He gave me quite a severe ticking office and said if I ever ever spoke out of turn like that again I would receive a disciplinary and might get sacked."

Marjorie Wallace - now chief executive of the charity Sane - also visited the hospital regularly in the 1980s when she was researching a book.

She said there was "obviously something sinister" about the DJ and attempted to raise the alarm after witnessing his treatment of two female patients: "I went to the Department of Health and said 'What is Jimmy Savile doing here?"

But she says she was told Savile was bringing Broadmoor out of the "dark ages" and that he was a "good person, liberating this closed institution".

Labour's Andy Burnham said giving Savile "gold-plated keys" to the hospital was "one of the greatest failures in public protection and patient safety we've ever seen".

The shadow health secretary called for an over-arching, independent inquiry into the scandal.

"It would appear Savile was appointed to this role without any background checks at all," he told the BBC. "There needs to be more independent scrutiny of how the government of the day handled this."

Dr Sue Proctor

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Dr Sue Proctor on mortuary allegations - This clip contains some disturbing content

Reports have been issued on: St Catherine's Hospital (Birkenhead); Saxondale Mental Health Hospital; Portsmouth Royal Hospital; Dewsbury and District Hospital (including Pinderfields Hospital); High Royds Psychiatric Hospital; Cardiff Royal Infirmary; Great Ormond Street Hospital; Exeter Hospital; Ashworth Hospital; Barnet General Hospital; Booth Hall; De La Pole Hospital; Dryburn Hospital; Hammersmith Hospital; Leavesden Secure Mental Health Hospital; Marsden Hospital; Maudsley Hospital; Odstock Hospital; Prestwich Psychiatric Hospital; Queen Victoria Hospital, East Grinstead; Royal Victoria Infirmary; Queen Mary's Hospital, Carshalton; Whitby Memorial Hospital; Wythenshawe Hospital, and Woodhouse Eaves Children's Convalescent Homes in Leicester.

A report about Wheatfield's Hospice, which is run by the Sue Ryder charity, has also been released.

Leicestershire Police has launched an investigation after one victim of Savile, who was abused as a young boy at a children's convalescent home in Woodhouse Eaves, told an enquiry team the entertainer was involved in the death of another child.

However, no reference to a child's death could be found in the records of the home, Roecliffe Manor, which closed in 1969.

Analysis by Nick Triggle, health correspondent, BBC News

Since the allegations about Jimmy Savile came to light, the police have looked into how many victims there may have been. A review of why he was never prosecuted has also been carried out.

But this is the most comprehensive account of how he was able to offend and get away with it for so long.

Reviews into his behaviour at the BBC and care homes are expected later this year - and will no doubt shed even more light on the scandal.

But for now the failings of the NHS - an institution that is there to care for the vulnerable - are in the spotlight.

He enjoyed unsupervised access, particularly at two sites, Leeds General Infirmary and Broadmoor psychiatric hospital, and was able to use his fame to intimidate junior staff.

What is more, senior management were too unquestioning.

The reports are loathe to blame individuals.

But with cases of abuse and improper conduct being reported up until 2009 - albeit much less frequently than in the 1960s and 1970s - the NHS has a lot of soul-searching to do.

Hospital bedroom

A key report into Savile's activities at Stoke Mandeville Hospital has been delayed after new information recently came to light.

Savile had a bedroom at Stoke Mandeville, where his now-defunct charitable trust was based, as well as an office and living quarters at Broadmoor.

Reports concerning two other hospitals - Rampton and Barnet, Enfield and Haringey Mental Health Trust - have also been delayed.

There are also new investigations at Springfield Hospital and Crawley Hospital.

It is understood investigations at two hospitals - the Royal Free Hospital in London and Pennine Acute NHS hospitals Trust - found nothing to report.

The revelations made in a 2012 ITV documentary about Savile prompted more than 100 people to come forward, giving accounts of how they were sexually assaulted by Savile on NHS premises and in other places.

A report by the NSPCC said Savile abused at least 500 victims, including some as young as two.

BBC health reporter Pippa Stephens said there have been many significant changes in the law since the time Savile committed abuse.

Hospitals' Savile reports

Hospital Number of allegations Details

Leeds General Infirmary(inc St James and Seacroft Hospital)

60

33 of the 60 alleged victims were patients of whom 19 were children. A further 19 were staff. Encounters ranged from lewd remarks and inappropriate touching to sexual assault and rape.

Broadmoor Hospital

11

10 victims of assault, two were repeatedly abused. Six patients, two children and two staff. One indecent exposure to child. Report found "clear, repeated failure of safeguarding standards" at Broadmoor at the time.

St Catherine's Hospital, Birkenhead

1

Savile allegedly groped a 14-year-old female patient. Report found the victim credible and convincing. Metropolitan police have recorded it as a crime of sexual touching.

Saxondale Mental Health Hospital

1

Woman who was then 14 alleges that Savile lifted her skirt when she was at a disco at the hospital. She was a local resident rather than a patient. Savile had a fundraising association with Saxondale Hospital from 1972 to the early 1980s.

Portsmouth Royal Hospital

1

A man alleges being told by a cleaner that he was assaulted by Savile while unconscious. The report concludes that it is "highly unlikely" the incident took place.

Dewsbury and District Hospital (inc Pinderfields Hospital)

2

Woman says that when she was a 15-year-old inpatient in 1969 Savile French kissed her without permission. A second allegation relates to lewd comments overheard by a nurse.

High Royds Psychiatric Hospital

2

Patient and member of staff say they were groped by Savile at a hospital fun day. Victim accounts described as "very compelling and certainly plausible".

Wheatfield's Hospice, (non-NHS – Sue Ryder)

1

At an opening ceremony before patients were admitted, a woman who was then 16 alleges that Savile touched her leg and made lewd comments. The report found her account credible but there was no evidence to substantiate it.

Cardiff Royal Infirmary

1

Patient alleged that Savile forcefully kissed her while she was lying in bed. The investigators were "unable to reach a conclusion about whether the incident took place".

Great Ormond Street

1

One allegation of sexual abuse of a patient in 1971. Report found no evidence that Savile was at the hospital at the time.

Digby Hospital, Exeter

1

Former patient alleges that she was raped by Savile in a caravan in the hospital grounds. The report "no reason to doubt the veracity" of her account.

Ashworth / Moss Side Hospital

4

Two female ex-patients said Savile abused them. One male ex-patient said he witnessed groping. One ex-staff member speculated about abuse which may have happened. Information was found to be credible.

Barnet General Hospital

1

Patient had conversation with nurses who said they had seen Savile having sex with dead body at a different hospital. Investigators concluded incident did not happen at Barnet although conversation did take place.

Booth Hall Children's Hospital

2

Woman who was 7 or 8 at time says she was abused by her father and Savile. Man says Savile touched him when he was 10. Investigators cannot say conclusively whether the incidents took place.

De La Pole Hospital

1

Nurse alleged Savile groped a 14-16-year-old female patient but she denies the incident. Investigators found no evidence of the alleged assault but did find Savile had visited the hospital.

Dryburn Hospital

1

Allegations of potential procuring of children for Savile. No evidence was found to support this.

Hammersmith Hospital

2

One allegation related to a friend of Savile rather than Savile himself. A second allegation was of an inappropriate comment to a 13-year-old girl. No evidence of an association between the hospital and Savile.

Leavesden Secure Mental Health Hospital

0

Person thought Savile may have visited the hospital in the 1970s but report finds this unlikely.

Royal Marsden Hospital

1

Person said colleague had alleged Savile had made sexual advances to her at either the Royal Marsden or Stoke Mandeville hospitals. No evidence was found of Savile's association with Royal Marsden.

Maudsley Hospital

0

Person thought Savile may have visited in 1964/5. Report found no evidence of wrongdoing.

Odstock Hospital, Salisbury

0

Person said Savile used to visit the hospital in the 1980s. Report found no allegation of wrongdoing by Savile.

Prestwich Psychiatric Hospital

1

Woman alleges that when she was a young girl she was taken onto the hospital site by Savile and another man and abused. Report found that the alleged incident had probably occurred despite not being possible to verify her account.

Queen Victoria Hospital, East Grinstead

1

Female patient alleged she was groped as she recovered from an operation. Investigators did not doubt that the attack happened but thought Savile was not involved.

Royal Victoria Infirmary

0

People flagged up that Savile had visited the hospital in 1987 and 1991. No allegation of wrongdoing made.

Queen Mary's Hospital

1

Anonymous allegation that a junior nurse denied Savile access to a ward and was threatened that a BBC outside broadcast would be cancelled as a result. Investigators found it was not possible to conclude whether the incident occurred.

Whitby Memorial Hospital

1

Staff member said Savile had touched her inappropriately. Investigators found that the incident did take place.

Wythenshawe Hospital

1

Patient said that a fellow patient alleged that Savile was a "dirty old man" who had parties in his home with young girls. No evidence that Savile was present on the hospital site.

Woodhouse Eaves / Roecliffe Manor

1

Allegation of abuse against a boy aged 5-7. Investigators found that it was likely that abuse had happened at the location but it was not possible to conclude it was carried out by Savile.


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Call to halve target for added sugar

26 June 2014 Last updated at 15:09 By James Gallagher Health editor, BBC News website

People need to more than halve their intake of added sugar to tackle the obesity crisis, according to scientific advice for the government in England.

A draft report by the Scientific Advisory Committee on Nutrition (SACN) says sugar added to food or naturally present in fruit juice and honey should account for 5% of energy intake.

Many fail to meet the old 10% target.

The sugar industry said "demonising one ingredient" would not "solve the obesity epidemic".

The body reviewed 600 scientific studies on the evidence of carbohydrates - including sugar - on health to develop the new recommendations.

One 330ml can of fizzy pop would take a typical adult up to the proposed 5% daily allowance, without factoring in sugar from any other source.

Jeremy Paxman with a can of Coca-cola

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Coca Cola Europe boss James Quincey confronted by Newsnight's Jeremy Paxman in November 2013

Prof Ian MacDonald, chairman of the SACN working group on carbohydrates, said: "The evidence that we have analysed shows quite clearly that high free sugars intake in adults is associated with increased energy intake and obesity.

"There is also an association between sugar-sweetened beverages and type-2 diabetes.

"In children there is clear demonstration that sugar-sweetened beverages are associated with obesity.

"By reducing it to 5% you would reduce the risk of all of those things, the challenge will be to get there."

The target of 5% of energy intake from free sugars amounts to 25g for women (five to six teaspoons) and 35g (seven to eight teaspoons) for men, based on the average diet.

'Silver bullet'

Public Health England will now reconsider its recommendations on fruit juice and smoothies in its five-a-day campaign.

The current advice from the NHS is that juice counts as a maximum of one portion a day, while a smoothie may count as more than one portion, depending on how it is made.

It will also investigate measures to protect children from food advertising while online and whether a sugar tax would have any merit.

Dr Alison Tedstone, the chief nutritionist at Public Health England, said: "We are very concerned around sugar intakes in England.

"It doesn't mean having a completely different diet from today, it is thinking about swapping high sugar foods for a lower sugar alternative.

"Instead of fizzy drink, have water or low-fat milk, instead of a chocolate bar, have a piece of fruit."

Analysis

By James Gallagher, Health editor, BBC news online

There's something noticeably missing from a call to halve added sugar - how would you go about doing it?

This group was set up to assess the science and determine what we should be eating. Its role was not to come up with policies.

The target of 5% is a huge challenge when teenagers are currently getting 15% of their calories from added sugar.

One option that doctors have called for is a tax on sugary drinks. The measure is being tried in Mexico, although there is still little evidence on its impact.

The tough decisions are all still to come - what measures will the public accept and how can we be encouraged to eat less sugar without driving us back into the arms of saturated fat and salt?

BBC News: Five foods surprisingly high in sugar

BBC News: The family that gave up sugar

The SACN advice echoes an announcement by the World Health Organization in March.

Its draft guidelines reiterated that sugars should constitute no more than 10% of energy intake and that people and governments should be aiming for 5%.

The limits would apply to all sugars added to food, as well as sugar naturally present in honey, syrups, fruit juices and fruit concentrates.

The Food and Drink Federation, which represents manufacturers, said: "SACN's comprehensive analysis of the evidence on carbohydrates has looked at the role of carbohydrates, including sugars and fibre in the diet. We will look at the content of the report and its recommendations over the next few weeks with the intention of engaging in the consultation process and related discussions."

Dr Julian Cooper, head of food science at AB Sugar, said targeting sugar was not a "silver bullet" and people should balance their calorie intake against how much they exercise.

'Fantastic'

The campaign group, Action on Sugar, said the development was "fantastic" news.

The group's chairman Prof Graham MacGregor argued: "Health Secretary Jeremy Hunt must start by setting targets for reducing sugar in soft drinks this summer and move responsibility for nutrition to an independent body such as the Food Standards Agency so that the soft drinks and food industry are given a level playing field, with the threat of regulation to ensure the whole of the food industry comply.

"Before another million British kids become obese."

Public Health Minister for England, Jane Ellison, said: "We know eating too much sugar can have a significant impact on health, and this draft advice confirms that.

"We want to help people make healthier choices and get the nation into healthy habits for life. This report will inform the important debate taking place about sugar."


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Leukaemia clue in breast cancer

27 June 2014 Last updated at 00:42

Leukaemia research may lead to new drugs for difficult-to-treat breast cancers, say scientists.

These types of tumours cannot be treated with the targeted drugs which have hugely improved survival.

A team in Glasgow says a faulty piece of DNA which causes leukaemia also has a role in some tumours and could help in research for new drugs.

Meanwhile, other researchers say they have taken tentative steps towards a blood test for breast cancer.

Oestrogen or progesterone positive breast cancers can be treated with hormone therapies such as Tamoxifen.

Another drug, Herceptin, works only on those tumours which are HER2-positive.

But around one in five breast cancers is "triple negative" meaning chemotherapy, radiotherapy or surgery are the only options.

Leukaemia

A team at the University of Glasgow investigated the role of the RUNX1 gene, which is one of the most commonly altered genes in leukaemia.

However, they have now shown it is also active in the most deadly of triple negative breast cancers.

Tests on 483 triple negative breast cancers showed patients testing positive for RUNX1 were four times more likely to die as a result of the cancer than those without it.

The results were published in the journal PLoS One.

One of the researchers, Dr Karen Blyth, said: "This opens up the exciting possibility of using it [RUNX1] as a new target for treatments."

She told the BBC: "First we need to prove this gene is causative to the cancer, if it is then what would happen if we did inhibit it?

"There's a couple of drugs in development in the US to target this gene from a leukaemia point of view, if they work we can test it in breast cancer cells."

However, the gene has a complex role. Normally it is vital for cell survival and plays a critical role in producing blood. However, depending on circumstances, it can either encourage or suppress tumours.

It means any use of a drug to target the gene might cause side-effects.

Dr Kat Arney, the science communications manager at Cancer Research UK, said: "There's still so much we need to understand about triple negative breast cancers, as they can be harder to treat in some people.

"Almost two out of three women with breast cancer now survive their disease beyond 20 years.

"But more must be done and we urgently need more studies like these, particularly in lesser-understood forms of the disease, to build on the progress we've already made and save more lives."

Blood test

In a separate development, scientists at University College London think they have taken the first steps towards a blood test for breast cancer.

They found changes in the DNA of immune cells in the blood of women who were at high risk of breast cancer as they had inherited the BRCA1 risk gene.

Prof Martin Widschwendter, from UCL said: "Surprisingly, we found the same signature in large cohorts of women without the BRCA1 mutation and it was able to predict breast cancer risk several years before diagnosis."

They think it could become the basis of a blood test.

Dr Matthew Lam, senior research officer at Breakthrough Breast Cancer, said: "These results are definitely promising and we're excited to learn how further research could build on these findings."


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