Ebola drug given to US aid workers

Written By Unknown on Selasa, 05 Agustus 2014 | 21.24

5 August 2014 Last updated at 12:59

US aid workers who contracted Ebola in Liberia appear to be improving after receiving an experimental drug, officials have said.

But it is not clear if the ZMapp drug, which has only been tested on monkeys, can be credited with their improvement.

Dr Kent Brantly was flown home for treatment on Saturday and his colleague Nancy Writebol left Liberia in the early hours of Tuesday.

Since February, 887 people have died of Ebola in four West African countries.

The World Bank is allocating $200m (£120m) in emergency assistance for countries battling to contain the Ebola outbreak.

Dr Anthony Fauci

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It is the world's deadliest outbreak to date and has centred on Guinea, Liberia and Sierra Leone. There have also been two cases in the Nigerian city of Lagos, where eight people are currently in quarantine.

The virus spreads by contact with infected blood and bodily fluids and the current outbreak is killing between 50% and 60% of people infected.

There is no cure or vaccine for Ebola - but patients have a better chance of survival if they receive early treatment.

Dr Anthony Fauci, director of the US National Institute of Allergy and Infectious Diseases, says clinical trials are to start in September on an Ebola vaccine that has shown promising results during tests on animals.

"By the middle to end of 2015 we'll be able to have some vaccine - at least to vaccinate health workers - who put themselves at considerable risk when they take care of these patients," he told the BBC's Newsday programme.

The US aid workers were treated with the ZMapp serum before their evacuation from Liberia.

According to a CNN report, quoting a doctor in Liberia, Dr Brantly's condition improved dramatically within an hour of receiving the drug.

Jim Yong Kim

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Service in Mission (SIM), the Christian aid group that employs Ms Writebol, says she has had two doses of the drug and did not respond as well as Dr Brantly but she is showing "improvement".

"She is walking with assistance... strength is better... has an appetite," SIM spokesman Palmer Holt told the Washington Post newspaper in an email on Monday.

Ms Writebol is on her way to a special isolation ward at Atlanta's Emory University Hospital, where Dr Kent Brantly is being treated by infectious disease specialists.

Three companies, the US government and the Public Health Agency of Canada are behind the experimental drug.

"ZMapp was first identified as a drug candidate in January 2014 and has not yet been evaluated for safety in humans. As such, very little of the drug is currently available," Mapp Biopharmaceutical said in a statement.

"Mapp and its partners are co-operating with appropriate government agencies to increase production as quickly as possible."

Ebola has initial flu-like symptoms that can lead to external haemorrhaging from areas like eyes and gums, and internal bleeding which can lead to organ failure.

African leaders attending the first-ever US-Africa summit are expected to discuss the crisis in Washington.

Ebola virus disease (EVD)
  • Symptoms include high fever, bleeding and central nervous system damage
  • Fatality rate can reach 90% - but the current outbreak is about 55%
  • Incubation period is two to 21 days
  • There is no vaccine or cure
  • Supportive care such as rehydrating patients who have diarrhoea and vomiting can help recovery
  • Fruit bats are considered to be virus' natural host

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