The rules for creating babies from three people in the UK have been announced.
The fertility technique uses material from the mother, father and a donor woman to prevent deadly diseases.
MPs will soon vote on whether to make the UK the first country in the world to legalise the procedure.
Opponents say it is unethical to make babies with DNA from three people and that it represents a "slippery slope" to designer babies.
Some families have lost seven children to "mitochondrial diseases" that leave the body with insufficient energy to function.
Mitochondria are the microscopic power stations in nearly every cell of the body.
Defective mitochondria are passed only from mother to child so scientists in the UK have pioneered therapies which use functioning mitochondria from a donor woman.
However, mitochondria have a tiny amount of their own DNA so any resulting child would have genetic information from three people.
The structure of a cellNucleus: Where the majority of our DNA is held - this determines how we look and our personality
Mitochondria: Often described as the cells' power stations, these convert energy into a form cells can use
Cytoplasm: The jelly like substance that contains the nucleus and mitochondria
The regulations put before Parliament state:
- The fertility regulator must assess each case for a significant risk of disability or serious illness
- Fertility clinics would need a new license to offer the technique
- The woman donating her egg would not be related to the child
- Any child born would have no right to information about the donor
In practice it means that only the most severely affected women - perhaps 10 cases per year - would go ahead.
And doctors in Newcastle, where the technique has been pioneered, would initially be the centre offering it.
The regulations will remain in draft form until they are voted on by Parliament and are signed off by ministers.
This is expected to take place before the general election in May 2015.
Public health minister Jane Ellison said: "The Government considers that the time is now right to give Parliament the opportunity to consider and vote on these regulations."
A scientific review by the fertility regulator, the Human Fertilisation and Embryology Authority, said doctors would be ready to start creating babies from three people in around two years.
The Human Fertilisation and Embryology Authority said there was no evidence that it would be unsafe, but called for final checks.
DeadlyBaby Jessica was born with Leigh's disease, a type of mitochondrial disease, and she has to be fed through a tube.
One in every 6,500 babies has severe mitochondrial disease.
"They did warn us she may not reach her toddler years," her mum Victoria Holliday said.
She, and partner Keith Newell, want more children, but are unwilling to risk another child suffering in the same way as Jessica.
"It's not fair that if there's a scientific technique out there that could stop this happening in the future that we're not using it," Victoria said.
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