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Royal doctor knighted in honours

Written By Unknown on Selasa, 31 Desember 2013 | 21.24

30 December 2013 Last updated at 17:57 ET

The Queen's physician who led the team that delivered the Duke and Duchess of Cambridge's baby has been made a Knight Commander of the Royal Victorian Order.

The award recognises Sir Marcus Setchell's services to the Royal Household over more than two decades.

As well as attending to Kate's extreme morning sickness in early 2013, he assisted with the Duchess of Cornwall's hysterectomy in 2007.

And he helped save the Countess of Wessex and her eldest child.

In 2003, Prince Edward's wife Sophie was rushed to hospital after complaining of severe internal pains when she was eight months pregnant.

She was dangerously ill from blood loss and needed an emergency Caesarean.

Sir Marcus, now 70, is due to retire.

The consultant obstetrician had been awarded Commander of the Royal Victorian Order in 2005.

Awards made under the Royal Victorian Order are in the Queen's personal gift and are bestowed independently of 10 Downing Street.

Caroline Cassels, matron of King Edward VII's Hospital, which has provided medical treatment for royals for decades, has been made a Lieutenant of the RVO.


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Mid Staffs campaigners honoured

30 December 2013 Last updated at 17:59 ET By James Gallagher Health and science reporter, BBC News

Two women who led the fight against one of the most shocking failings in NHS history have been recognised in the New Year honours list.

The care at Stafford Hospital left some patients drinking water from vases, it is claimed, and receptionists assessing emergency cases.

Julie Bailey, who set up the campaign group Cure the NHS after witnessing her mother's treatment, was made a CBE.

Helene Donnelly, a nurse who became a whistleblower, was made an OBE.

Figures suggested there were more deaths than would have been expected at Stafford Hospital between 2005 and 2008.

Patients needing pain relief either got it late or not at all, leaving them crying out for help, and there were cases where food and drinks were left out of reach.

Helene Donnelly worked in the A&E department at the hospital.

She raised nearly 100 complaints about the treatment of patients, turned whistleblower and was a key witness at the Stafford Hospital public inquiry.

She told the BBC she was "tremendously proud and honoured" to receive the OBE for services to the NHS, after what had been a "very difficult time personally and professionally".

Ms Donnelly said she was surprised when she found out: "It was rather surreal really, I was completely shocked, I thought is this some sort of mistake?"

She is now an ambassador for cultural change at the Staffordshire and Stoke-on-Trent Partnership NHS Trust and takes staff concerns directly to the chief executive.

"I hope this [honour] is recognition for lots of other people trying to raise concerns and this is also for the positive change we're trying to encourage now."

Campaign to cure

Julie Bailey, who led the campaign for a public inquiry into failings at the hospital, was given a CBE for "services to the care of older people".

Her 86-year-old mother Bella collapsed in the hospital in 2007 after being left without her oxygen supply.

Ms Bailey spent the next eight weeks sleeping on the ward after resolving that her mother should not be left alone in the hospital.

She said she witnessed "utter chaos" on the ward with patients drinking out of flower vases.

Her mother later died at the hospital and Ms Bailey set up the Cure the NHS campaign group with other relatives of patients who had died at the hospital.

Previous inquiries into care had been held in private. The group successfully campaigned for a full public inquiry which concluded in 2013.

Since then new rules, to make hospitals in England publish monthly details of whether they have enough nurses on their wards and making a criminal offence of wilful neglect to hold staff to account, have been announced.


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Charities expect alcohol abuse rise

31 December 2013 Last updated at 02:03 ET

More people are expected to seek help from drug and alcohol charities over the new year.

Three of the biggest services in Wales - Cais in north Wales, Sands Cymru in Swansea and Inroads in Cardiff - say they are preparing for their busiest time of year.

Charity workers said relapses and alcohol were often the biggest issues.

This was because people had been overdoing it over Christmas or were lonely.

"For us, I would say for the last five years we've definitely seen an increase in the number of people coming to us at the start of each year," said Ifor Glyn, chief executive of Sands Cymru.

"As far as the type of people coming in, alcohol and heroin are the main ones we are seeing."

Mr Glyn said people with alcohol problems spanned all ages and social classes from a lecturer to a homeless person.

He added: "People want to party and one of the best ways to change their mood is to take a substance.

"People tend to realise after new year that they've overdone it and they are seeing some of the effects of what they've done.

Drug overdoses

"It's also a time when a lot of people will get depressed and get quite lonely and take drugs to forget about things."

Continue reading the main story

Individuals who are trying to control their drinking find it very difficult to do it at a time of year when celebrations are around drinking"

End Quote Clive Wolfendale Cais

Mr Glyn said the charity tried to promote sensible drinking and raise awareness of underage drinking and drink-driving in a bid to help tackle the problem.

But it also wants more done to prevent avoidable drug overdoses after 37 people died in Swansea in the last two years while a further 25 lives were saved.

An awareness day, which involved sessions for drug users and professionals, was held earlier this month.

Clive Wolfendale, chief executive of Cais, said the charity would mostly see people with alcohol problems turn to them for help in January.

"Individuals who are trying to control their drinking find it very difficult to do it at a time of year when celebrations are around drinking," he said.

"It's difficult to stay apart from the festivities and celebrations that surround Christmas.

"We do get calls. It's a time for reflection. It's like an extreme example of a new year's resolution."

Mr Wolfendale said Cais would be open throughout the festive period for people who needed help.

In Cardiff, Mags Lyons, project manager at Inroads, said alcohol was a year-round problem.

"Alcohol is the front-runner for everything, not just over the festive period," she said. "But we do see more people after new year.

"There's lots of family disruptions and it's a highly emotional time. It's mostly alcohol. People think it's okay to get wasted. But people then start counting the cost."


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Breast implants to be registered

Written By Unknown on Senin, 30 Desember 2013 | 21.24

29 December 2013 Last updated at 03:53 ET By James Gallagher Health and science reporter, BBC News

Every breast implant operation in England is to be recorded on a new register, ministers have announced.

A lack of records meant some surgeons were unable to tell their patients if they were affected by the recent scare over sub-standard PIP implants.

Ministers said they were cleaning up a "cowboy industry" steeped in "murky practices".

Health ministers in Wales, Scotland and Northern Ireland will decide if they are to join the register.

Continue reading the main story

James Gallagher Health and science reporter, BBC News


This could just be a tease of what is to come.

There has been widespread admission that regulations have not kept up with the increasing array and popularity of cosmetic procedures.

For example dermal fillers, to plump up the skin, and buttock implants are deemed to have no medical purpose so are regulated in the same way as toothbrushes and ball-point pens.

And procedures such as Botox injections, which have the potential to go horribly wrong, have become commonplace at "beauty parties".

A review made a series of recommendations including the breast implant register.

This should help women if there is a repeat of the PIP scandal.

The government still has to tackle the other recommendations such as calls for legislation to make fillers prescription only and formal qualifications for anyone injecting Botox.

The full response is expected early in the New Year.

Fresh efforts will also be made to regulate adverts to end the era of "win a boob-job" competitions.

The cosmetic procedures industry has been quietly booming. It was worth £750m in the UK in 2005, £2.3bn in 2010 and is forecast to reach £3.6bn by 2015.

However, the PIP implant scandal led doctors to describe the field as a poorly regulated "crisis waiting to happen".

The French company Poly Implant Prothese sold faulty implants containing sub-standard silicone gel with double the rupture rate of other implants.

It caused a global scare affecting 300,000 women.

'Data-free zone'

A review described the UK as a "data-free zone" with a serious lack of records about which women had been given PIP implants or what had happened to them.

The NHS and some private companies will trial a new system for registering implants, similar to the National Joint Registry for hip operations, before making it compulsory across England.

Dr Dan Poulter, health minister for England, told the BBC: "The PIP implant scandal has shone a light on what is sometimes a cowboy industry where there are some murky practices.

Dr Rajiv Grover

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Dr Rajiv Grover, British Association of Aesthetic Plastic Surgeons: Register "must be compulsory"

"What we need to do is more effectively track the quality of implants women receive and to make sure that when things go wrong with those implants, that can be acted on as quickly as possible - setting up a register will help us to do that."

The Department of Health also said it was working with the Advertising Standards Authority (ASA) to tackle "irresponsible marketing" such as buy-one-get-one-free deals and competitions for men to "win a boob-job" for their girlfriends.

The ASA has already banned adverts from companies advertising "Boob jobs - more affordable than you may think" for "trivialising breast enhancement surgery".

Dr Poulter said: "That sort of marketing is irresponsible because it can change the way a woman looks for the rest of their life and we need to see greater responsibility from the cosmetic industry in how they advertise themselves and we're going to clamp down."

'Early warning system'

The Royal College of Surgeons will also create new qualifications and professional standards for cosmetic surgery.

Rajiv Grover, consultant plastic surgeon and president of the British Association of Aesthetic Plastic Surgeons (BAAPS), said: "Whilst we're pleased there is to be a clampdown on time-linked incentives that place undue pressure on the public, we continue to call for an outright ban on all advertising of medical procedures.

"People considering cosmetic surgery have a lot to think about: possible risks, their own expectations, the qualifications of the provider, recovery - whether there's a Christmas sale, a two-for-one if they book by Friday... should never play a part in a sensible decision-making process."

Vicky Ashton, who had PIP implants and is part of a campaign group for those women affected, told BBC News changes in the industry were not coming "far enough fast enough".

"What is taking the government so long and why on earth are they just piloting this scheme? It should have been rolled out months and months ago, and everybody should be forced to take part in it."

She added: "My main concern is this is great going forward, but what about the women that are affected now - what [is the government] doing for them?"

Mr Simon Withey, a consultant plastic surgeon and part of the panel which reviewed the industry, told the BBC: "The rhetoric is it's a cowboy industry. It's not. Most surgeons are excellent, but it doesn't take many poor ones to wreak havoc."

He said a breast implant register was "exactly the right thing to do".

"It acts as an early warning system of product failure which would have been helpful in PIP and it is now critical that if there are any product failures in the future that we can track patients as quickly as possible."


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Migrants to face NHS care charges

29 December 2013 Last updated at 19:56 ET
Lord Howe

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Lord Howe: "We've got to get better at detecting them (health tourists)"

Migrants and overseas visitors are to face new charges for some NHS services in England, ministers say.

They include extended prescription fees, the introduction of charges for some emergency care and higher rates for optical and dental services.

However, GP and nurse consultations will remain free, and nobody will be turned away in an emergency.

Ministers say they are keen to clamp down on any abuse of the system, but doctors' leaders have voiced concerns.

The government had considered charging for GP consultations, but decided that easy initial access was important to prevent risks to public health such as HIV, TB and sexually transmitted infections.

Other types of primary care services that are being considered for charging include minor surgery that is carried out by a GP and physiotherapy that has been referred through a GP.

There are also plans to introduce a new system for identifying and recording patients who should be charged for NHS services.

Specific details of how the plans will be implemented are due to be unveiled in March 2014.

Continue reading the main story
  • Free NHS care is offered to anyone living in the UK who has temporary or permanent permission to do so
  • Asylum seekers, non-European Economic Area nationals who do not have permission to live in the UK, British expats, and visitors usually have to pay for treatment
  • The UK has reciprocal agreements with most European nations and 28 other countries, and under these visitors are given free NHS care
  • The NHS should claim these costs back from the relevant governments - but research suggests just £73m a year is recouped out of more than £460m at present.

The government said the changes would allow the NHS to recoup money, and encourage only those who need urgent and emergency care to attend.

Health Minister Lord Howe said: "Having a universal health service free at the point of use rightly makes us the envy of the world, but we must make sure the system is fair to the hardworking British taxpayers who fund it.

"We know that we need to make changes across the NHS to better identify and charge visitors and migrants. Introducing charging at primary care is the first step to achieving this.

"We are already looking at taking action and next year we will set out our detailed plans to clamp down on the abuse of our NHS."

'Unintended drawbacks'

The British Medical Association said it was concerned the proposals would require doctors and GPs to spend more time on paperwork and that it could cost more in administration charges than what it would recuperate.

Dr Mark Porter, chairman of the BMA Council, said: "The government's current proposals could create unintended drawbacks for the NHS and patients.

GP wearing a stethoscope

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"They are likely to create a complex patchwork of charging and access entitlements where some services remain free, such as GP appointments, while others will be chargeable, including A&E visits and other services provided via many GP practices, such as physiotherapy."

Dr Chaand Nagpaul, who leads the BMA's GP committee, added: "We cannot have a situation where any patient with a serious health need is deterred from visiting a GP, especially if their condition raises a potential public health risk."

Labour shadow health minister Lord Hunt accused ministers of "putting spin before substance".

"Labour is in favour of improving the recovery of costs from people with no entitlement to NHS treatment," he said.

"Rather than more grand-standing, the government needs to deliver practical, thought-through changes to make that happen.

"Instead this out-of-touch government is left asking doctors and nurses to act as surrogate immigration officials."

The announcement follows a Department of Health study which estimated that up to £500m could be recovered from overseas visitors' and migrants' use of the NHS every year through better charging.

However, academics have argued that the extent of deliberate health tourism - where people travel to the UK specifically to use the NHS - has been hugely overstated and is responsible for only a small part of NHS expenditure.

The government has already announced a £200-a-year levy on migrants from outside the European Economic Area staying for between six months and five years.

A cost-recovery unit will help hospitals claw back money they are owed by other governments for treating foreign nationals visiting the UK.


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Call to restrict e-cigarette sales

30 December 2013 Last updated at 05:43 ET

Restrictions should be placed on the sale of electronic cigarettes to prevent them being bought by children, according to an MSP.

The SNP's Stewart Maxwell said there was no age limit on buying e-cigarettes - although many contained nicotine.

He wants the Scottish government to see if anything can be done to close this loophole.

The MSP has also called for the UK government to set out firmer rules on the advertising of such products.

Sales of tobacco-free cigarettes have boomed worldwide since bans on smoking in public places were introduced.

Health campaigners have said their growing popularity could undermine years of anti-smoking efforts, with particular concerns about promotion to children and non-smokers.

But others have argued the electronic alternative to tobacco could help save hundreds of thousands of lives.

Continue reading the main story

We cannot have a situation where we return to the bad old days where nicotine products were glamorised in advertising"

End Quote Stewart Maxwell MSP SNP

Research suggests about 1.3m smokers and ex-smokers in the UK use the products, which are designed to replicate smoking behaviour without the use of tobacco.

E-cigarettes turn nicotine and other chemicals into a vapour that is inhaled.

Mr Maxwell said an answer to a Westminster parliamentary question revealed that there were currently no age restrictions affecting the sale of e-cigarettes.

"There is a real and worrying grey area when it comes to e-cigarettes that needs to be addressed," he said.

"It cannot be right that these nicotine-containing products can be legally marketed and sold to children.

"There is a worrying loophole here that needs to be tightened up as a matter of urgency. I will be seeking a meeting with the Scottish government minister for public health to see if anything can be done in Scotland to close this loophole in the sale of these products, but clearly there is also need for action at Westminster."

Electronic cigarettes will be licensed as a medicine in the UK from 2016 under new regulations to be introduced by the Medicines and Healthcare Products Regulation Agency, the body which regulates medicines in the UK.

The UK currently has few restrictions on the use of e-cigarettes, despite moves in some countries to ban them.

Mr Maxwell added: "Scotland currently does not have the power to restrict the advertising of these products, something that is vital if this issue is to be tackled properly.

"All our experience with tobacco products shows that advertising plays a huge role in how products like this are perceived. We cannot have a situation where we return to the bad old days where nicotine products were glamorised in advertising.

"There needs to be firmer rules on what exactly is permitted, so that we do not find ourselves in a position where products that encourage nicotine addiction are ever seen as healthy or beneficial."

A spokesman for the Scottish government said: "We will continue to consider what further advice and guidance may be required on electronic cigarettes for the benefit of public health in Scotland and the minister for public health, Michael Matheson, would be happy to meet Mr Maxwell to discuss this matter."


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New genetic clues for arthritis

Written By Unknown on Sabtu, 28 Desember 2013 | 21.24

25 December 2013 Last updated at 13:03 ET Pallab GhoshBy Pallab Ghosh Science correspondent, BBC News

An international team of researchers has found more than 40 new areas in DNA that increase the risk of rheumatoid arthritis.

The work is the largest genetic study ever carried out, involving nearly 30,000 patients.

The investigators believe new drugs could be developed to target these areas that could one day provide a cure for the disease.

The findings are published in the Journal Nature.

Continue reading the main story

"Start Quote

What this offers in the future is an opportunity to use genetics to discover new medicines for complex diseases like rheumatoid arthritis and to treat or even cure the disease"

End Quote Prof Robert Plenge Harvard Medical School

The research team compared the DNA of arthritis patients with those without the disease and found 42 'faulty' areas that were linked with the disease. The hope is that drugs can be developed to compensate for these faults.

The lead researcher Professor Robert Plenge of Harvard Medical School found that one of these areas produced a weakness that was treated by an existing drug that was developed by trial and error, rather than specifically made to correct the genetic problem.

This finding, he says, shows such discoveries could be used to design new drugs.

"What this offers in the future is an opportunity to use genetics to discover new medicines for complex diseases like rheumatoid arthritis to treat or even cure the disease," he said.

Complex diseases

Some have argued identifying genetic weak areas for complex diseases - known as single nucleotide polymorphisms (SNPs) - is not useful. There is little or no evidence, they argue, that "silencing the SNPs" with drugs will relieve any symptoms.

But Dr Plenge says the fact that he has found an established drug that treats the symptoms that arise from a particular SNP for rheumatoid arthritis validates this genetic approach.

Continue reading the main story

"Start Quote

There are already therapies that have been designed in the cancer field that might open up new opportunities for retargeting drugs"

End Quote Prof Jane Worthington Director, Centre for Genetics

"It offers tremendous potential. This approach could be used to identify drug targets for complex diseases, nut just rheumatoid arthritis, but diabetes, Alzheimer's and coronary heart disease"

Fast track

The study also found SNPs in the rheumatoid arthritis patients that also occur in patients with types of blood cancer.

According to Prof Jane Worthington, director of the centre for genetics in Manchester, this observation suggests that drugs that are being used to treat the cancer could be effective against rheumatoid arthritis and so should be fast tracked into clinical trials.

"There are already therapies that have been designed in the cancer field that might open up new opportunities for retargeting drugs," she told BBC News.

"It might allow us a straightforward way to add therapies we have to treat patients with rheumatoid arthritis".

Follow Pallab on Twitter


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Trust apologises over DNA failings

27 December 2013 Last updated at 04:52 ET

An NHS Trust has apologised for "inexcusable failings" at a sexual assault referral centre in London after complaints that samples were not sent to forensic laboratories for DNA tests.

Two staff members have been dismissed from the Haven in Whitechapel and the centre is under new management.

NHS England said results from some samples had also not been passed on. It said 93 clients were affected.

Barts Health NHS Trust said swift action was taken to retest samples.

An NHS England spokesman said "a serious incident was raised" in 2011 and "an immediate investigation carried out" at the Haven in Whitechapel.

"This investigation unearthed a further issue of results from samples having been received but not passed on to clients," he added.

"A total of 93 clients were affected by the two issues."

Confidential report

Since April 2013, when NHS England was established, the commissioning arrangements for the Haven have changed.

Continue reading the main story

We are extremely sorry for the inexcusable failings at the Whitechapel Haven"

End Quote Barts Health NHS Trust

NHS England said all three Havens in London - in Whitechapel, Paddington and Camberwell - were now managed by King's College Hospital NHS Foundation Trust.

Camberwell and Paddington Havens were not affected by the incident.

The Haven in Whitechapel has reopened but is yet to provide a full 24-hour service.

Barts Health NHS Trust said in a statement: "We are extremely sorry for the inexcusable failings at the Whitechapel Haven.

"As soon as we became aware that there was an issue in 2011, we took swift and immediate action to ensure that all the affected samples were retested and contacted the individuals involved to offer a full apology, support and counselling."

The Independent newspaper says it has seen a confidential report into the incident, obtained by the Bureau of Investigative Journalism.

The paper reports that dozens of samples taken from victims of sexual attacks had been left in a fridge instead of being sent for forensic analysis.

Staff described working in "an oppressive, tense environment" and told investigators they dreaded shifts but were afraid to complain to managers, the Independent said.

The paper said the report had not been made public while the trust said it had "strived for transparency throughout".

Staff 'commended'

The trust said there had been no suggestion it had acted in an inappropriate way during the investigation.

It said: "The independent investigation report commented on the diligence, honesty and openness of our staff in working together to discover and correct what had gone wrong."

The trust also pointed out that its staff had been commended "for the quality of individual care provided to those accessing the service".

NHS England said: "The trust took swift and immediate action working with the Metropolitan Police to ensure that forensic testing took place without further delay on all samples affected.

"Immediate steps were taken to contact each client, whose samples had not been sent for testing, as well as those whose samples had been tested but who had not been informed of the results.

"They received a full apology and were invited to make an appointment with a trained counsellor to receive the results and continued support."

Liz Kendall, Shadow Social Care Minister, said the report should have been immediately published.

"The women who have been affected have a right to know who is responsible for the unacceptable failings at Whitechapel Haven and that they are properly held to account.

"Complete transparency is also essential to ensure similar services for rape victims learn the lessons from what has happened to make sure these appalling mistakes never happen again."


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Diabetes risk 'from Neanderthals'

25 December 2013 Last updated at 13:27 ET By Paul Rincon Science editor, BBC News website

A gene variant that seems to increase the risk of diabetes in Latin Americans appears to have been inherited from Neanderthals, a study suggests.

We now know that modern humans interbred with a population of Neanderthals shortly after leaving Africa 60,000-70,000 years ago.

This means that Neanderthal genes are now scattered across the genomes of all non-Africans living today.

Details of the study appear in the journal Nature.

The gene variant was detected in a large genome-wide association study (GWAS) of more than 8,000 Mexicans and other Latin Americans. The GWAS approach looks at many genes in different individuals, to see whether they are linked with a particular trait.

People who carry the higher risk version of the gene are 25% more likely to have diabetes than those who do not, and people who inherited copies from both parents are 50% more likely to have diabetes.

The higher risk form of the gene - named SLC16A11 - has been found in up to half of people with recent Native American ancestry, including Latin Americans.

Drug hope

The variant is found in about 20% of East Asians and is rare in populations from Europe and Africa.

Continue reading the main story

This could illuminate new pathways to target with drugs and a deeper understanding of the disease"

End Quote Prof Jose Florez Harvard Medical School

The elevated frequency of this variant in Latin Americans could account for as much as 20% of these populations' increased prevalence of type 2 diabetes - the origins of which are complex and poorly understood.

"To date, genetic studies have largely used samples from people of European or Asian ancestry, which makes it possible to miss culprit genes that are altered at different frequencies in other populations," said co-author Jose Florez, associate professor of medicine at Harvard Medical School in Massachusetts.

"By expanding our search to include samples from Mexico and Latin America, we've found one of the strongest genetic risk factors discovered to date, which could illuminate new pathways to target with drugs and a deeper understanding of the disease."

The team that discovered the variant carried out additional analyses, in collaboration with Svante Paabo of the Max Planck Institute for Evolutionary Anthropology.

They discovered that the SLC16A11 sequence associated with risk of type 2 diabetes is found in a newly sequenced Neanderthal genome from Denisova Cave in Siberia.

Analyses indicate that the higher risk version of SLC16A11 was introduced into modern humans through interbreeding between early modern humans and Neanderthals.

It is not unusual to find Neanderthal genes. About 2% of the genomes of present-day non-Africans were inherited from this distinctive human group, which lived across Europe and western Asia from about 400,000-300,000 years ago until 30,000 years ago.

But scientists are only just beginning to understand the functional implications of this Neanderthal inheritance.

"One of the most exciting aspects of this work is that we've uncovered a new clue about the biology of diabetes," said co-author David Altshuler, who is based at the Broad Institute in Massachusetts.

SLC16A11 is part of a family of genes that code for proteins that transport metabolites - molecules involved in the body's various chemical reactions.

Altering the levels of the SLC16A11 protein can change the amount of a type of fat that has been implicated in the risk of diabetes. These findings suggest that SLC16A11 could be involved in the transport of an unknown metabolite that affects fat levels in cells and thereby increases risk of type 2 diabetes.


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Diabetes risk 'from Neanderthals'

Written By Unknown on Jumat, 27 Desember 2013 | 21.24

25 December 2013 Last updated at 13:27 ET By Paul Rincon Science editor, BBC News website

A gene variant that seems to increase the risk of diabetes in Latin Americans appears to have been inherited from Neanderthals, a study suggests.

We now know that modern humans interbred with a population of Neanderthals shortly after leaving Africa 60,000-70,000 years ago.

This means that Neanderthal genes are now scattered across the genomes of all non-Africans living today.

Details of the study appear in the journal Nature.

The gene variant was detected in a large genome-wide association study (GWAS) of more than 8,000 Mexicans and other Latin Americans. The GWAS approach looks at many genes in different individuals, to see whether they are linked with a particular trait.

People who carry the higher risk version of the gene are 25% more likely to have diabetes than those who do not, and people who inherited copies from both parents are 50% more likely to have diabetes.

The higher risk form of the gene - named SLC16A11 - has been found in up to half of people with recent Native American ancestry, including Latin Americans.

Drug hope

The variant is found in about 20% of East Asians and is rare in populations from Europe and Africa.

Continue reading the main story

This could illuminate new pathways to target with drugs and a deeper understanding of the disease"

End Quote Prof Jose Florez Harvard Medical School

The elevated frequency of this variant in Latin Americans could account for as much as 20% of these populations' increased prevalence of type 2 diabetes - the origins of which are complex and poorly understood.

"To date, genetic studies have largely used samples from people of European or Asian ancestry, which makes it possible to miss culprit genes that are altered at different frequencies in other populations," said co-author Jose Florez, associate professor of medicine at Harvard Medical School in Massachusetts.

"By expanding our search to include samples from Mexico and Latin America, we've found one of the strongest genetic risk factors discovered to date, which could illuminate new pathways to target with drugs and a deeper understanding of the disease."

The team that discovered the variant carried out additional analyses, in collaboration with Svante Paabo of the Max Planck Institute for Evolutionary Anthropology.

They discovered that the SLC16A11 sequence associated with risk of type 2 diabetes is found in a newly sequenced Neanderthal genome from Denisova Cave in Siberia.

Analyses indicate that the higher risk version of SLC16A11 was introduced into modern humans through interbreeding between early modern humans and Neanderthals.

It is not unusual to find Neanderthal genes. About 2% of the genomes of present-day non-Africans were inherited from this distinctive human group, which lived across Europe and western Asia from about 400,000-300,000 years ago until 30,000 years ago.

But scientists are only just beginning to understand the functional implications of this Neanderthal inheritance.

"One of the most exciting aspects of this work is that we've uncovered a new clue about the biology of diabetes," said co-author David Altshuler, who is based at the Broad Institute in Massachusetts.

SLC16A11 is part of a family of genes that code for proteins that transport metabolites - molecules involved in the body's various chemical reactions.

Altering the levels of the SLC16A11 protein can change the amount of a type of fat that has been implicated in the risk of diabetes. These findings suggest that SLC16A11 could be involved in the transport of an unknown metabolite that affects fat levels in cells and thereby increases risk of type 2 diabetes.


21.24 | 0 komentar | Read More

New genetic clues for arthritis

25 December 2013 Last updated at 13:03 ET Pallab GhoshBy Pallab Ghosh Science correspondent, BBC News

An international team of researchers has found more than 40 new areas in DNA that increase the risk of rheumatoid arthritis.

The work is the largest genetic study ever carried out, involving nearly 30,000 patients.

The investigators believe new drugs could be developed to target these areas that could one day provide a cure for the disease.

The findings are published in the Journal Nature.

Continue reading the main story

"Start Quote

What this offers in the future is an opportunity to use genetics to discover new medicines for complex diseases like rheumatoid arthritis and to treat or even cure the disease"

End Quote Prof Robert Plenge Harvard Medical School

The research team compared the DNA of arthritis patients with those without the disease and found 42 'faulty' areas that were linked with the disease. The hope is that drugs can be developed to compensate for these faults.

The lead researcher Professor Robert Plenge of Harvard Medical School found that one of these areas produced a weakness that was treated by an existing drug that was developed by trial and error, rather than specifically made to correct the genetic problem.

This finding, he says, shows such discoveries could be used to design new drugs.

"What this offers in the future is an opportunity to use genetics to discover new medicines for complex diseases like rheumatoid arthritis to treat or even cure the disease," he said.

Complex diseases

Some have argued identifying genetic weak areas for complex diseases - known as single nucleotide polymorphisms (SNPs) - is not useful. There is little or no evidence, they argue, that "silencing the SNPs" with drugs will relieve any symptoms.

But Dr Plenge says the fact that he has found an established drug that treats the symptoms that arise from a particular SNP for rheumatoid arthritis validates this genetic approach.

Continue reading the main story

"Start Quote

There are already therapies that have been designed in the cancer field that might open up new opportunities for retargeting drugs"

End Quote Prof Jane Worthington Director, Centre for Genetics

"It offers tremendous potential. This approach could be used to identify drug targets for complex diseases, nut just rheumatoid arthritis, but diabetes, Alzheimer's and coronary heart disease"

Fast track

The study also found SNPs in the rheumatoid arthritis patients that also occur in patients with types of blood cancer.

According to Prof Jane Worthington, director of the centre for genetics in Manchester, this observation suggests that drugs that are being used to treat the cancer could be effective against rheumatoid arthritis and so should be fast tracked into clinical trials.

"There are already therapies that have been designed in the cancer field that might open up new opportunities for retargeting drugs," she told BBC News.

"It might allow us a straightforward way to add therapies we have to treat patients with rheumatoid arthritis".

Follow Pallab on Twitter


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Trust apologises over DNA failings

27 December 2013 Last updated at 04:52 ET

An NHS Trust has apologised for "inexcusable failings" at a sexual assault referral centre in London after complaints that samples were not sent to forensic laboratories for DNA tests.

Two staff members have been dismissed from the Haven in Whitechapel and the centre is under new management.

NHS England said results from some samples had also not been passed on. It said 93 clients were affected.

Barts Health NHS Trust said swift action was taken to retest samples.

An NHS England spokesman said "a serious incident was raised" in 2011 and "an immediate investigation carried out" at the Haven in Whitechapel.

"This investigation unearthed a further issue of results from samples having been received but not passed on to clients," he added.

"A total of 93 clients were affected by the two issues."

Confidential report

Since April 2013, when NHS England was established, the commissioning arrangements for the Haven have changed.

Continue reading the main story

We are extremely sorry for the inexcusable failings at the Whitechapel Haven"

End Quote Barts Health NHS Trust

NHS England said all three Havens in London - in Whitechapel, Paddington and Camberwell - were now managed by King's College Hospital NHS Foundation Trust.

Camberwell and Paddington Havens were not affected by the incident.

The Haven in Whitechapel has reopened but is yet to provide a full 24-hour service.

Barts Health NHS Trust said in a statement: "We are extremely sorry for the inexcusable failings at the Whitechapel Haven.

"As soon as we became aware that there was an issue in 2011, we took swift and immediate action to ensure that all the affected samples were retested and contacted the individuals involved to offer a full apology, support and counselling."

The Independent newspaper says it has seen a confidential report into the incident, obtained by the Bureau of Investigative Journalism.

The paper reports that dozens of samples taken from victims of sexual attacks had been left in a fridge instead of being sent for forensic analysis.

Staff described working in "an oppressive, tense environment" and told investigators they dreaded shifts but were afraid to complain to managers, the Independent said.

The paper said the report had not been made public while the trust said it had "strived for transparency throughout".

Staff 'commended'

The trust said there had been no suggestion it had acted in an inappropriate way during the investigation.

It said: "The independent investigation report commented on the diligence, honesty and openness of our staff in working together to discover and correct what had gone wrong."

The trust also pointed out that its staff had been commended "for the quality of individual care provided to those accessing the service".

NHS England said: "The trust took swift and immediate action working with the Metropolitan Police to ensure that forensic testing took place without further delay on all samples affected.

"Immediate steps were taken to contact each client, whose samples had not been sent for testing, as well as those whose samples had been tested but who had not been informed of the results.

"They received a full apology and were invited to make an appointment with a trained counsellor to receive the results and continued support."

Liz Kendall, Shadow Social Care Minister, said the report should have been immediately published.

"The women who have been affected have a right to know who is responsible for the unacceptable failings at Whitechapel Haven and that they are properly held to account.

"Complete transparency is also essential to ensure similar services for rape victims learn the lessons from what has happened to make sure these appalling mistakes never happen again."


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New genetic clues for arthritis

Written By Unknown on Kamis, 26 Desember 2013 | 21.24

25 December 2013 Last updated at 13:03 ET Pallab GhoshBy Pallab Ghosh Science correspondent, BBC News

An international team of researchers has found more than 40 new areas in DNA that increase the risk of rheumatoid arthritis.

The work is the largest genetic study ever carried out, involving nearly 30,000 patients.

The investigators believe new drugs could be developed to target these areas that could one day provide a cure for the disease.

The findings are published in the Journal Nature.

Continue reading the main story

"Start Quote

What this offers in the future is an opportunity to use genetics to discover new medicines for complex diseases like rheumatoid arthritis and to treat or even cure the disease"

End Quote Prof Robert Plenge Harvard Medical School

The research team compared the DNA of arthritis patients with those without the disease and found 42 'faulty' areas that were linked with the disease. The hope is that drugs can be developed to compensate for these faults.

The lead researcher Professor Robert Plenge of Harvard Medical School found that one of these areas produced a weakness that was treated by an existing drug that was developed by trial and error, rather than specifically made to correct the genetic problem.

This finding, he says, shows such discoveries could be used to design new drugs.

"What this offers in the future is an opportunity to use genetics to discover new medicines for complex diseases like rheumatoid arthritis to treat or even cure the disease," he said.

Complex diseases

Some have argued identifying genetic weak areas for complex diseases - known as single nucleotide polymorphisms (SNPs) - is not useful. There is little or no evidence, they argue, that "silencing the SNPs" with drugs will relieve any symptoms.

But Dr Plenge says the fact that he has found an established drug that treats the symptoms that arise from a particular SNP for rheumatoid arthritis validates this genetic approach.

Continue reading the main story

"Start Quote

There are already therapies that have been designed in the cancer field that might open up new opportunities for retargeting drugs"

End Quote Prof Jane Worthington Director, Centre for Genetics

"It offers tremendous potential. This approach could be used to identify drug targets for complex diseases, nut just rheumatoid arthritis, but diabetes, Alzheimer's and coronary heart disease"

Fast track

The study also found SNPs in the rheumatoid arthritis patients that also occur in patients with types of blood cancer.

According to Prof Jane Worthington, director of the centre for genetics in Manchester, this observation suggests that drugs that are being used to treat the cancer could be effective against rheumatoid arthritis and so should be fast tracked into clinical trials.

"There are already therapies that have been designed in the cancer field that might open up new opportunities for retargeting drugs," she told BBC News.

"It might allow us a straightforward way to add therapies we have to treat patients with rheumatoid arthritis".

Follow Pallab on Twitter


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Surgeon suspended over 'branding'

24 December 2013 Last updated at 08:38 ET

A doctor has been suspended over allegations he "branded" his initials on to a patient's liver.

University Hospitals Birmingham NHS Foundation Trust confirmed it is investigating the claims made against a surgeon at the Queen Elizabeth Hospital in Birmingham.

The letters were reportedly found by a colleague during a routine operation.

The trust said the surgeon had been suspended until an internal investigation is completed.


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Diabetes risk 'from Neanderthals'

25 December 2013 Last updated at 13:27 ET By Paul Rincon Science editor, BBC News website

A gene variant that seems to increase the risk of diabetes in Latin Americans appears to have been inherited from Neanderthals, a study suggests.

We now know that modern humans interbred with a population of Neanderthals shortly after leaving Africa 60,000-70,000 years ago.

This means that Neanderthal genes are now scattered across the genomes of all non-Africans living today.

Details of the study appear in the journal Nature.

The gene variant was detected in a large genome-wide association study (GWAS) of more than 8,000 Mexicans and other Latin Americans. The GWAS approach looks at many genes in different individuals, to see whether they are linked with a particular trait.

People who carry the higher risk version of the gene are 25% more likely to have diabetes than those who do not, and people who inherited copies from both parents are 50% more likely to have diabetes.

The higher risk form of the gene - named SLC16A11 - has been found in up to half of people with recent Native American ancestry, including Latin Americans.

Drug hope

The variant is found in about 20% of East Asians and is rare in populations from Europe and Africa.

Continue reading the main story

This could illuminate new pathways to target with drugs and a deeper understanding of the disease"

End Quote Prof Jose Florez Harvard Medical School

The elevated frequency of this variant in Latin Americans could account for as much as 20% of these populations' increased prevalence of type 2 diabetes - the origins of which are complex and poorly understood.

"To date, genetic studies have largely used samples from people of European or Asian ancestry, which makes it possible to miss culprit genes that are altered at different frequencies in other populations," said co-author Jose Florez, associate professor of medicine at Harvard Medical School in Massachusetts.

"By expanding our search to include samples from Mexico and Latin America, we've found one of the strongest genetic risk factors discovered to date, which could illuminate new pathways to target with drugs and a deeper understanding of the disease."

The team that discovered the variant carried out additional analyses, in collaboration with Svante Paabo of the Max Planck Institute for Evolutionary Anthropology.

They discovered that the SLC16A11 sequence associated with risk of type 2 diabetes is found in a newly sequenced Neanderthal genome from Denisova Cave in Siberia.

Analyses indicate that the higher risk version of SLC16A11 was introduced into modern humans through interbreeding between early modern humans and Neanderthals.

It is not unusual to find Neanderthal genes. About 2% of the genomes of present-day non-Africans were inherited from this distinctive human group, which lived across Europe and western Asia from about 400,000-300,000 years ago until 30,000 years ago.

But scientists are only just beginning to understand the functional implications of this Neanderthal inheritance.

"One of the most exciting aspects of this work is that we've uncovered a new clue about the biology of diabetes," said co-author David Altshuler, who is based at the Broad Institute in Massachusetts.

SLC16A11 is part of a family of genes that code for proteins that transport metabolites - molecules involved in the body's various chemical reactions.

Altering the levels of the SLC16A11 protein can change the amount of a type of fat that has been implicated in the risk of diabetes. These findings suggest that SLC16A11 could be involved in the transport of an unknown metabolite that affects fat levels in cells and thereby increases risk of type 2 diabetes.


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Surgeon suspended over 'branding'

Written By Unknown on Rabu, 25 Desember 2013 | 21.24

24 December 2013 Last updated at 08:38 ET

A doctor has been suspended over allegations he "branded" his initials on to a patient's liver.

University Hospitals Birmingham NHS Foundation Trust confirmed it is investigating the claims made against a surgeon at the Queen Elizabeth Hospital in Birmingham.

The letters were reportedly found by a colleague during a routine operation.

The trust said the surgeon had been suspended until an internal investigation is completed.


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Millions wait a week to see a GP

23 December 2013 Last updated at 19:11 ET

Millions of patients in England wait a week or longer to be seen by their GP surgery, official NHS figures reveal.

The Royal College of General Practitioners, which analysed the data, says it expects the delays to worsen.

It says demand is growing due to a rising population, yet fewer trainee doctors are being directed to general practice to meet this need, rather than hospital medicine.

This will put more pressure on accident and emergency departments, it warns.

Prescription

Please turn on JavaScript. Media requires JavaScript to play.

If people cannot see their GP promptly, some will visit the emergency department instead, says the RCGP.

According to NHS England's latest GP Patient Survey, the proportion of patients in England who are having to wait a week or more for an appointment has risen to 15%, compared to 14% a year ago.

Based on these findings, the RCGP estimates some 26.2m patients waited a week or more to see or speak to their GP, and 46.8m waited a week or more to see of speak to a GP or nurse at their practice.

But the GP Patient Survey data, involving nearly 1m respondents, also shows 92.2% of people find making a GP appointment convenient.

Stretched services

The RCGP says more investment is needed in general practice, which currently receives just over 8% of the total NHS budget.

And it wants more graduates to be trained as GPs.

In 2012 - the latest year for which figures are available - there were 31,700 GPs compared to 38,200 hospital doctors.

RCGP Chair Dr Maureen Baker said: "It is vital to ensure that patients are able to access their local GP quickly and effectively - just as it is important for hospitals to have adequate numbers of qualified consultants to look after patients who are in need of acute health care.

"We need to ensure that we have enough GPs to provide patients with good access to high-quality health care in local communities across the UK."

She warned: "If waiting times get longer, it will be more difficult for GPs to ensure that problems are caught early, and the pressure on A&E will intensify. This is bad news for patients and bad news for the whole of the NHS."

Health Minister Dr Dan Poulter said: "The recent GP survey showed that 86% of patients rate their overall experience of their GP practice as good.

"We have announced a £50 million fund to support innovative GP practices to improve access for their patients so that people who lead busy lives will have better access to GP services when it suits them."

He also said: "We have a commitment to increase the number of GP trainees to 50% of all medical students by 2020 and we expect GP numbers to continue to grow faster than the population."

Dr Mike Bewick, Deputy Medical Director for NHS England said: "We are aware of the challenges with recruitment, retention and inequity in the distribution of the general practice workforce, with planning in primary care not as strong as other specialties."

He said work was under way to develop general practice fit for the future.

Labour blamed the waits on the current government's decision in 2010 to scrap a target that guaranteed patients a GP appointment within 48 hours.


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Minister orders mid Wales NHS report

24 December 2013 Last updated at 19:35 ET

The Welsh health minister has decided to order a report on the future of health services in mid Wales.

Mark Drakeford's move comes in the wake of a meeting with Ceredigion AM Elin Jones and a delegation of senior clinicians from Ceredigion and Powys.

They urged the minister to consider the particular needs of the sparsely-populated, largely rural counties when planning future health services.

BBC Wales has asked Hywel Dda and Powys Teaching Health Boards to comment.

Mr Drakeford confirmed he had decided to commission an independently-led piece of research into the future shape of health services in the region in a letter sent to Ms Jones on 19 December.

Continue reading the main story

The kinds of solutions which are relevant in urban areas aren't always applicable to us"

End Quote Elin Jones Plaid Cymru AM for Ceredigion
'Rural setting'

Ms Jones, the Plaid Cymru spokesperson on health, said: "I'm heartened by the health minister's positive response to the delegation of respected clinicians whom he met last month.

"This decision confirms that the minister accepts that there are unique and specific challenges faced by a rural hospital and its catchment area.

"There is a huge gap between the hospitals along the M4 and A55 corridors in Wales, with only Bronglais Hospital in Aberystwyth in between.

"The kinds of solutions which are relevant in urban areas aren't always applicable to us.

"We face huge challenges over issues such as how to attract staff to Bronglais Hospital, how to ensure that GPs can train locally and be appointed to take over when family doctors retire, and how the NHS interacts with other services in a rural setting.

"It's essential that this research is independent of the health boards, and consults fully with local medical practitioners."

The development comes after Ceredigion council decided to pass a motion of no confidence in Hywel Dda Health Board earlier in December.

This followed the health board's decision to close Cardigan community hospital to inpatients.

The hospital will remain open to outpatients but beds will be provided in nursing homes in the community.

The health board insists no beds will be lost to the county, with a new hospital in the pipeline.

A deal has been struck to open a £20m hospital in the town in the future, which includes a GPs' surgery.

More than 2,500 people have signed a petition to reverse the health board's decision which was launched by the Friends of Cardigan Hospital and Cardigan Town Council on 13 December.

A Welsh government spokesman said: "The Health Minister will commission a study to look into the issues and identify potential solutions for providing accessible, high quality, safe, and sustainable services to meet the specific needs of those living in mid Wales.

"The minister is expected to announce further details in the New Year."


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Millions wait a week to see a GP

Written By Unknown on Selasa, 24 Desember 2013 | 21.24

23 December 2013 Last updated at 19:11 ET

Millions of patients in England wait a week or longer to be seen by their GP surgery, official NHS figures reveal.

The Royal College of General Practitioners, which analysed the data, says it expects the delays to worsen.

It says demand is growing due to a rising population, yet fewer trainee doctors are being directed to general practice to meet this need, rather than hospital medicine.

This will put more pressure on accident and emergency departments, it warns.

Prescription

Please turn on JavaScript. Media requires JavaScript to play.

If people cannot see their GP promptly, some will visit the emergency department instead, says the RCGP.

According to NHS England's latest GP Patient Survey, the proportion of patients in England who are having to wait a week or more for an appointment has risen to 15%, compared to 14% a year ago.

Based on these findings, the RCGP estimates some 26.2m patients waited a week or more to see or speak to their GP, and 46.8m waited a week or more to see of speak to a GP or nurse at their practice.

But the GP Patient Survey data, involving nearly 1m respondents, also shows 92.2% of people find making a GP appointment convenient.

Stretched services

The RCGP says more investment is needed in general practice, which currently receives just over 8% of the total NHS budget.

And it wants more graduates to be trained as GPs.

In 2012 - the latest year for which figures are available - there were 31,700 GPs compared to 38,200 hospital doctors.

RCGP Chair Dr Maureen Baker said: "It is vital to ensure that patients are able to access their local GP quickly and effectively - just as it is important for hospitals to have adequate numbers of qualified consultants to look after patients who are in need of acute health care.

"We need to ensure that we have enough GPs to provide patients with good access to high-quality health care in local communities across the UK."

She warned: "If waiting times get longer, it will be more difficult for GPs to ensure that problems are caught early, and the pressure on A&E will intensify. This is bad news for patients and bad news for the whole of the NHS."

Health Minister Dr Dan Poulter said: "The recent GP survey showed that 86% of patients rate their overall experience of their GP practice as good.

"We have announced a £50 million fund to support innovative GP practices to improve access for their patients so that people who lead busy lives will have better access to GP services when it suits them."

He also said: "We have a commitment to increase the number of GP trainees to 50% of all medical students by 2020 and we expect GP numbers to continue to grow faster than the population."

Dr Mike Bewick, Deputy Medical Director for NHS England said: "We are aware of the challenges with recruitment, retention and inequity in the distribution of the general practice workforce, with planning in primary care not as strong as other specialties."

He said work was under way to develop general practice fit for the future.

Labour blamed the waits on the current government's decision in 2010 to scrap a target that guaranteed patients a GP appointment within 48 hours.


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Study backs eating nuts in pregnancy

23 December 2013 Last updated at 19:12 ET

Children are less likely to have a nut allergy if their mother ate nuts while pregnant, a study has concluded.

The work, published in JAMA Pediatrics, looked at the health and diets of more than 8,000 children and their mothers.

The US researchers believe that early exposure in the womb creates natural tolerance to certain foods.

But the findings conflict with other studies that have shown either no effect or a possible risk from nut consumption.

Continue reading the main story

Current international guidance is that there is no need to either avoid nuts, nor to actively eat them"

End Quote Dr Adam Fox, Consultant children's allergist at Guy's and St Thomas's NHS Foundation Trust

Experts say this makes it difficult to offer firm advice to mothers-to-be, with the exception of women who are themselves allergic to nuts and should therefore always avoid eating them.

Conflicting evidence

The study authors, led by Dr Lindsay Frazier of the Dana-Faber Children's Cancer in Boston, concluded children were a third less likely to have a nut allergy if their mothers had eating nuts during pregnancy.

This included tree nuts such as walnuts, almonds, pistachios, cashews, pecans, brazils, hazelnuts and macadamias as well as peanuts.

The authors say this suggests that nut consumption may protect against future allergies.

But there are other factors that may also explain this difference.

For example, the women who ate nuts were also more likely to have healthier diets containing plenty of fruit and vegetables.

Dr Adam Fox, consultant children's allergist at Guy's and St Thomas's NHS Foundation Trust, said the findings were interesting but inconclusive.

"To make things even more complicated, there is also strong evidence to suggest that nut allergy doesn't develop until after birth and that it is exposure of the infant's skin to nut protein that is most important in the development of allergy.

"With such differing results from different studies, it is currently impossible to offer advice about exactly what mothers should do regarding nut consumption during pregnancy but current international guidance is that there is no need to either avoid nuts, nor to actively eat them."


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Surgeon suspended over 'branding'

24 December 2013 Last updated at 08:38 ET

A doctor has been suspended over allegations he "branded" his initials on to a patient's liver.

University Hospitals Birmingham NHS Foundation Trust confirmed it is investigating the claims made against a surgeon at the Queen Elizabeth Hospital in Birmingham.

The letters were reportedly found by a colleague during a routine operation.

The trust said the surgeon had been suspended until an internal investigation is completed.


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Small changes 'lower diabetes risk'

Written By Unknown on Senin, 23 Desember 2013 | 21.24

22 December 2013 Last updated at 19:04 ET

Modest lifestyle changes in diet and activity by South Asian families improve their chance of losing weight to lower their risk of type 2 diabetes, according to a study.

Making moderate improvements could help to improve their health and wellbeing, an Edinburgh clinical trial has found.

The Edinburgh University study was carried out in their homes as opposed to hospital clinics.

It is the first of its kind in the UK to focus on South Asian cultures.

Patients lost weight and reduced their hip and waist measurements and there were indications they were less likely to become diabetic by the end of the trial, which focused on people of Indian and Pakistani-origin.

Researchers said ethnic background and culture played an important role in shaping attitudes and behaviours towards diet and exercise.

National guidelines show South Asian people place strong emphasis on family life and eating together.

Body mass index

From a young age, South Asians are said to be sensitive or at risk of health problems linked to obesity.

Men from Pakistani and Indian communities are three times more likely to develop type 2 diabetes than the general population, despite having similar body mass indexes, scientists said.

The three-year trial monitored 171 people of Indian and Pakistani background living in Scotland who were already at high risk of diabetes as shown by blood tests done at the start of the trial.

Participants were given detailed advice by dieticians and offered culturally-appropriate resources to help them manage their weight through diet and exercise.

At the same time, control groups were given basic advice, which was not culturally specific.

Professor Raj Bhopal, from Edinburgh University's centre for population health sciences, said: "These differing approaches show us that a more family-centred strategy, with culturally tailored lifestyle advice, can produce significant benefits to people's health through weight loss."

The trial is published in the journal Lancet Diabetes and Endocrinology.


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Christmas warning over fake alcohol

Steve HoldenBy Steve Holden
Newsbeat reporter in Leeds
Rebecca Lass is a trainee scientist

Please turn on JavaScript. Media requires JavaScript to play.

Rebecca Lass helps test for counterfeit alcohol

Trading standards is urging people to keep an eye out for fake alcohol over the Christmas period.

Over the past four years, its growing prevalence has led to it becoming one of the most investigated counterfeit goods in the UK.

Fake alcohol, usually vodka or white spirits, can contain potentially harmful substances like chloroform.

In the past, off-licences and nightclubs have been fined for selling it.

Handley Brustad of the Trading Standards Institute said: "Trading standards professionals are keeping a wary eye for fake alcohol, particularly in the run-up to the holiday period.

"Anyone who is approached at car boot sales, markets or at offices with offers to buy alcohol at cheap prices should be wary because many of these products contain high levels of methanol, which is a poison and in some instances can kill."

Testing

The West Yorkshire Joint Services Laboratory in Leeds carries out tests to confirm that seized items are fake.

Twenty-year-old Rebecca Lass is one of the team.

"Counterfeit vodka is getting that good that you can't tell the difference, which is why we need to do the testing," she said.

"When it's diluted with cola or lemonade people can't actually taste that there's something off."

Continue reading the main story
  • Spelling mistakes on bottle
  • Cloudy looking liquid
  • Drinks deals that seem too good to be true
  • Brands you may be unfamiliar with - e.g. Drop

The process of confirming a fake product includes tests on the liquid's alcohol content and its connectivity.

Other industrial chemicals the lab have found include propanol and methanol.

Leeds nightclub Several hundred litres of fake vodka were found at this nightclub in Leeds

In September 2013, one nightclub in Leeds city centre was fined £5,000 after 656 litres of fake vodka was found on site.

Lee Swift, enforcement officer at West Yorkshire Trading Standards, said: "It's more tempting for shopkeepers, even clubs to some extent, to not go to their legitimate supply chain.

"There's the temptation of buying cheaper alcohol for cash."

According to the Wine and Spirit Trade Association, the alcohol industry is worth £37.7bn in the UK.

Criminals have sought to exploit that market.

A study by the Institute of Economic Affairs estimated counterfeit alcohol costs the treasury £1.2 billion every year.

Anyone who suspects their alcohol may be counterfeit is being urged to contact their local trading standards' service.


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Heston gives taste to hospital meals

23 December 2013 Last updated at 07:05 ET

TV chef Heston Blumenthal appears to have found the key ingredient to give elderly hospital patients an appetite.

Working with food scientists at the University of Reading, the bespectacled kitchen guru discovered ingredients rich in the fifth basic taste, umami, makes food more appealing.

In a trial with 31 elderly patients his enhanced meals were a clear winner over regular hospital dishes.

A dash of Worcester sauce, soy or ketchup may be enough, the work shows.

The enhanced recipe put to the test was Heston's cottage pie.

Patients were asked to eat as much or as little of it as they wanted. They were also offered a standard cottage pie for comparison but were not told which of the two dishes was Heston's.

Overall, the patients rated the TV chef's meal as far tastier, the journal Nutrition and Aging reports.

They also ate more of it, but more trials are needed to see whether Heston's recipes will prevent malnutrition by getting patients to eat more.

Around one in three people admitted to hospital or care homes in the UK are found to be malnourished or at risk of malnourishment.

Flavour in foods, especially savoury ones, is enhanced by umami - known as the fifth taste, and also the Japanese word for delicious and savoury.

The umami taste is due to the detection of an amino acid common in meat, cheese, broth, stock, and other protein-rich foods.

The other four tastes are salt, sour, sweet and bitter.


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Fake vodka 'can kill you' warning

Written By Unknown on Minggu, 22 Desember 2013 | 21.24

20 December 2013 Last updated at 19:08 ET By Brian Milligan Personal Finance Reporter, BBC News

Christmas shoppers trying to save money are being warned to look out for counterfeit alcohol, which can seriously damage health.

Trading standards say it may contain chemicals such as chloroform or industrial alcohol, which can affect eyesight, or in extreme cases, kill.

Seizures of counterfeit vodka in some areas doubled over the last year.

Typically it is sold in corner shops where unscrupulous owners sell it from underneath the counter.

It has also been found on sale in nightclubs.

"I was silly enough to buy some stuff from under the counter, which was clearly not a proper manufactured product," admits Alex Kohnert, a student at Sheffield University.

Continue reading the main story

Fake vodka seizures in Sheffield

  • 2011/12: 554 bottles
  • 2012/13: 1,470
  • 2013/14: 2,370

"I have friends who've suffered from temporary blindness, in one case, but also quite bad stomach pains," he told the BBC.

13,000 litres

Trading Standards staff in Sheffield have been particularly aggressive in trying to tackle the problem.

Since April this year they have found 2,300 bottles of illicit alcohol, mostly vodka. That is double the amount they found last year, which in turn was double what they found in 2011.

Usually it contains alcohols used in cleaning fluids or antifreeze. As a result, such bottles can contain up to 57% alcohol.

"It's not tested. There's no quality control," says Ian Ashmore of Trading Standards.

"These are often criminals that are manufacturing this. They're not concerned about the consumer's health. So it can contain virtually anything," he says.

In once recent case, a shopkeeper in the Richmond area of Sheffield was fined £582, including costs, for keeping 674 bottles of counterfeit vodka under the counter.

The council called the fine derisory.

Nerve damage

The problem is now becoming apparent elsewhere across the country too.

Continue reading the main story

"Start Quote

You can lose your eyesight; you can lose your ability to walk like a normal person; You can lose your life."

End Quote Dr Sarah Jarvis Drinkaware

In August, a nightclub in Leeds was fined for stocking vodka containing chloroform, an anaesthetic which can make you feel dizzy, and even cause a drinker to lose consciousness.

In September, HMRC seized 13,000 litres of counterfeit vodka in Scotland, one of the largest such seizures ever.

It was being transported from Belfast and the lorry was intercepted as it left the ferry at Cairnryan.

In December 2013, the owner of a nightclub in Chelmsford was fined after selling fake Smirnoff which he had bought from a van just outside the club.

Doctors warn that any fake alcohol which contains methanol can be particularly dangerous.

Dr Sarah Jarvis, who advises the organisation Drinkaware, says it can cause nerve damage, giving the victim symptoms of Parkinson's disease.

"You can lose your eyesight; you can lose your ability to walk like a normal person; you can lose your life," she told the BBC.

How to spot it

Spotting a fake is not always easy. Most illegal manufacturers try and imitate the UK duty paid stamp, although often it is the wrong size.

One bottle of vodka we saw claimed to come from an area called "Russia-Berlin", which ought to ring alarm bells.

Others had spelling mistakes, wonky labels, and even sediment in the bottle.

But some bottles looked exactly like their genuine counterparts, such as Smirnoff or Selekt. Some had an extremely pungent aroma.

Price is another good indicator. The duty and VAT alone on a legitimate 70cl bottle of vodka total £8.89.

"So if you see a bottle on sale for any less than £9.50, I would be inspecting it," said Ken Webb, an enforcement officer with Trading Standards.

Becca Barnes, a welfare officer at Sheffield University, is particularly concerned about students who tank themselves up early in the evening.

"We've had students who've started drinking before a night out," she says.

"Our advice is to look carefully at the prices as you shop."

Drinkware advises shoppers to think of four 'Ps':

  • Place: Buy in a reputable location.
  • Price: If it is too cheap, be careful.
  • Packaging: Check if the labels are correct, or have been tampered with.
  • Product: If it smells or looks bad, do not drink it.

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Hunt 'crazy' to call hospital bosses

21 December 2013 Last updated at 12:09 ET

It is "crazy" for Health Secretary Jeremy Hunt to personally call hospital bosses who miss A&E targets, the health regulator for England has said.

David Prior, chairman of the Care Quality Commission, told the Daily Telegraph it was an "obsession".

The Department of Health said Mr Hunt "would not be doing his job" if he did not keep in touch with frontline staff at hospitals.

This has previously included phoning chief executives.

Mr Prior also criticised the "target culture" in the NHS but the health secretary's spokesman said patients needed guarantees.

Labour responded by defending the use of targets, which were brought in while it was in power. Shadow health minister Jamie Reed said they had cut waiting lists and increased patient satisfaction.

But Dr Richard Vautry, deputy chairman of the BMA's GP committee, said they did not help to improve morale among staff, "and can sometimes hinder the ability to improve our services".

'Held accountable'

In the interview, Mr Prior, the head of health regulator the CQC, criticised Mr Hunt for directly calling hospital chief executives, saying: "There is an obsession. It's crazy to have a secretary of state doing that.

"Of course he's doing it because he's held accountable, but what it all leads to is more money being put into A&E departments when that money should probably be put into primary and community care to stop people falling ill," he added.

Mr Prior, a former Conservative MP and deputy party chairman, also voiced concern over targets.

"The whole culture of the NHS became so focused on targets that it obscured what real quality was about. The voice of the patient wasn't in those targets," he said.

Mr Prior said that when patients arrived in A&E "the clock starts ticking and not a lot happens".

"At three hours people start to get interested - and at three hours 55 minutes the chief executive is down in the A&E department. That doesn't make any sense," he said.

The NHS in England has waiting time targets of four hours for patients in A&E.

Mr Prior also said he felt the NHS "became too powerful to criticise" despite many patients receiving a "wholly unsatisfactory" service.

Missed targets

Stephen Dorrell, chairman of the Commons Health Select Committee, said Mr Hunt should not try to "micro manage" hospitals.

"There are too many of them and the secretary of state doesn't have the necessary expertise," he said.

A Department of Health spokesman said: "Jeremy Hunt would not be doing his job if he wasn't keeping in touch with hospitals on the front line in the run-up to winter and talking and listening regularly to feedback about how things are going."

A spokesman for Mr Hunt said some targets, including those for A&E waiting times, had been relaxed and others scrapped since the coalition came to power.

However, he said there was a "balance" to be struck because the public needed guarantees that they would be treated quickly.

The spokesman also defended the performance of A&E units, saying they were "holding up well" and more people than ever before were being seen within four hours.

Mr Reed said: "In 1997 people were waiting for months and years to be seen and receive treatment, but by 2010 targets had helped to deliver the lowest ever waiting lists and patient satisfaction was at a record high. That is why this government has continued to use targets.

"The focus now needs to be on the winter crisis engulfing A&E. When Labour left office, 98% of patients were seen within four hours, but the government continues to miss its own lowered A&E target."


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Spotlight on elderly malnutrition

22 December 2013 Last updated at 08:56 ET
Lyn Isden cooking

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Jay Isden's mother Lyn lost two dress sizes

A project is being launched to raise awareness of malnutrition among elderly people, with government backing.

Nearly a million over-65s in England suffer from untreated malnutrition, says charity Age UK - almost all of whom are in the community.

The project will aim to identify individuals in this group and support those who need help to eat properly.

Age UK, which is leading the work, said it wanted to ensure people did not "slip through the net".

More hospital admissions

The Malnutrition Prevention Project will begin in January.

There will be pilots in five areas, including Lambeth in south London and Salford, and these will involve hospitals, GPs, social care, care homes and community groups.

The project will target people with low body mass index [that is, people who are underweight] and those who appear to be losing weight without trying - signs that are often wrongly seen as a normal part of ageing.

Dr Mike Stroud

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Dr Mike Stroud, from the Malnutrition Task Force, says the project will focus on helping the elderly in homes, hospitals and care homes

It is part of the government's response to the Francis report into events at Stafford Hospital - which found patients, many of them elderly, had not been able to eat or drink properly and that nutrition was not treated as a priority.

However, research has shown that 93% of malnourished older people are in the community.

Being malnourished can mean medication is less effective if it should be taken on a full stomach - and this makes it harder to recover from illness.

Compared with well-nourished people, those who are malnourished see their GP twice as often, have three times the number of hospital admissions and stay in hospital more than three days longer, the experts behind the project say.

Eating social activity
Continue reading the main story

My dad is almost 89 and insists on living alone. I buy him healthy food but throw it away every week and I am sure he lies to me about what he is eating.

He insists on corned beef, scotch eggs, rice pudding, trifle, eggs and olives along at least a litre of brandy a week! The healthiest thing he eats are bananas.

I think this task force is a very good idea because parents like my dad would listen to them and us children and relatives are not trained for it.

When he was in hospital and someone cooked a meal for him he ate it, but he won't cook for himself.

There must be more people who worry sick, especially at this time of year, so anything anybody can do to help would be brilliant.

Vivien Helliwell

Dianne Jeffrey, chairman of Age UK, also chairs the Malnutrition Task Force expert group behind the project.

She said eating and drinking properly was "critical to being healthy and remaining independent".

But, she added, malnutrition went untreated and undiagnosed in "nearly one million older people in England"

"We hope that by working closely with hospitals, GP surgeries and care homes, we can tackle this hidden problem and help ensure that older people do not slip through the net."

David McCullough, chief executive of the Royal Voluntary Service, a charity that helps older people stay active, told BBC Radio 5 Live: "This is not a money problem, it is about the sort of changes people go through when they get older.

"A lot of us think that part of getting older is losing weight but it is not a standard thing and is an indication of people not eating properly.

"Eating on your own is not much fun - eating is something, for most of us, we do with friends and family.

"When people are stuck at home alone they tend to eat less and drink less and that has really quite profound consequences for their health."

The Task Force will bring together a number of organisations and parts of the community to deal with the issue.

"We want to raise awareness and figure out the easy ways of us all identifying this problem so that we can jump in and deal with it," Mr McCullough added.

Health minister Dan Poulter said: "Many people think of malnutrition as a problem that only affects the third world.

"But the reality is that over three million people in the UK have the potential to become malnourished - many of whom are frail and elderly."

He said action was needed. "Carers and NHS staff will be better equipped to identify, tackle and prevent malnutrition - so older people get better care and receive more support in their own homes and communities."


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